Qhov sib txawv tseem ceeb ntawm naive thiab effector T Cells yog qhov tsis paub T hlwb yog T hlwb uas muaj qhov sib txawv tab sis tseem tsis tau ntsib lawv cov antigens sib xws, thaum effector T hlwb yog T hlwb tsim los ntawm naive T hlwb tom qab lawv tau ntsib. lawv cov antigens sib thooj.
T hlwb yog ib feem tseem ceeb ntawm lub cev tiv thaiv kab mob. Lawv yog cov hlwb tshwj xeeb tsim los tua cov kab mob uas ua rau lawv tsis tau ntsib. Lawv sib txawv hauv cov thymus kom txog thaum tso tawm rau hauv cov hlab ntsha li naive T hlwb. Thaum ib tug naive T cell ntsib ib tug paub APC (antigen-presenting cell), nws hloov mus rau effector T hlwb xws li cytotoxic T hlwb thiab pab T hlwb.
Naive T Cells yog dab tsi?
Naive T cells (Th0 cells) yog T hlwb uas tau sib txawv thiab tso tawm los ntawm thymus tab sis tseem tsis tau ntsib lawv cov antigens sib xws. Ib tug naive T cell feem ntau yog T cell uas tau sib txawv hauv thymus thiab ua tiav cov txheej txheem zoo thiab tsis zoo ntawm kev xaiv hauv nruab nrab hauv thymus. Ntawm cov neeg T hlwb no, cov ntaub ntawv tsis tseeb ntawm tus pab T hlwb (CD4+) thiab cytotoxic T hlwb (CD8+) suav nrog. Tsis zoo li activated T cell, ib tug naive T cell yog suav hais tias tsis paub qab hau. Ntxiv mus, ib tug naive T cell tseem tsis tau ntsib nws cognate antigen nyob rau hauv periphery.
Daim duab 01: Naive T Cells
Naive T hlwb teb rau cov kab mob tshiab uas lub cev tiv thaiv kab mob tseem tsis tau ntsib. Tom qab ib tug naive T cell paub nws cov cognate antigen, nws pib lub cev tiv thaiv kab mob. Qhov no ua rau T cell tau txais ib qho activated phenotype pom los ntawm kev txhim kho ntawm cov cim saum npoo xws li CD25+, CD44+, CD62L. low, thiab CD69+ Tsis tas li ntawd, lawv tuaj yeem sib txawv ntxiv rau hauv lub cim xeeb T hlwb ib yam nkaus.
Effector T Cells yog dab tsi?
Effector T cells yog T hlwb uas tsim los ntawm cov neeg tsis paub T hlwb tom qab lawv ntsib lawv cov antigens sib raug. Thaum naive T hlwb paub txog ib qho antigen, lawv tau txais peb hom teeb liab: lub teeb liab antigen los ntawm TCR lossis BCR, co-stimulatory teeb liab, thiab cytokine teeb liab. Yog hais tias ib tug naive T cell tau txais tag nrho cov saum toj no peb lub cim, nws txawv rau hauv ib tug effector cell. Cov effector T cell subsets suav nrog CD8+ T cells (killer cells), CD4+ T hlwb (cov pab hlwb), thiab tswj T hlwb.
Daim duab 02: Effector T Cells
Cytotoxic T hlwb muaj lub luag haujlwm tseem ceeb ntawm kev tua cov kab mob lom. Thaum lees paub, lawv tshem tawm cov kab mob kis kab mob, cov kab mob, thiab cov qog nqaij hlav los ntawm cov txheej txheem hu ua apoptosis. Cov neeg pab txhawb nqa T hlwb sib npaug thiab zais cov cytokines uas hu cov macrophages thiab cytotoxic T hlwb mus rau qhov chaw kis kab mob. Tsis tas li ntawd, kev tswj hwm T hlwb tau ua haujlwm los tiv thaiv kev tiv thaiv kab mob autoimmune thaum qhov kev hem thawj tau raug tshem tawm. Qee zaum, qee hom T lymphocytes tshwm sim txawm tias tom qab tshem tawm cov kab mob. Cov T-hlwb uas nyob ntev no hu ua lub cim xeeb T hlwb. Cov T hlwb nco no muaj peev xwm teb tau cov antigens thaum rov pib dua.
Dab tsi yog qhov zoo sib xws ntawm Naive thiab Effector T Cells?
- Naive thiab effector T cells yog ob hom T hlwb hauv lub cev tiv thaiv kab mob.
- Ob leeg muaj nyob rau hauv cov hlab ntsha.
- Lawv sib txawv T cells.
- Ob leeg ntawm no ua haujlwm sib koom ua ke los pib lub cev tiv thaiv kab mob rau cov kab mob.
- Muaj cov lej txaus ntawm cov neeg tsis paub lus thiab cov txiaj ntsig T hlwb yog qhov tseem ceeb rau lub cev tiv thaiv kab mob los teb rau cov kab mob tsis paub txuas ntxiv.
Qhov txawv ntawm Naive thiab Effector T Cells yog dab tsi?
Naive T hlwb yog T hlwb uas muaj qhov sib txawv tab sis tseem tsis tau ntsib lawv cov antigens sib xws, thaum effector T hlwb yog T hlwb tsim los ntawm naive T hlwb tom qab lawv tau ntsib lawv cov antigens sib xws. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm naive thiab effector T hlwb. Tsis tas li ntawd, cov hlwb tsis paub tseeb yog suav tias tsis paub tab thiab tsis ua haujlwm, thaum lub hlwb T hlwb raug suav tias paub tab thiab qhib.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm naive thiab effector T hlwb hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Naive vs Effector T Cells
Naive thiab effector T hlwb yog ob hom T hlwb hauv lub cev tiv thaiv kab mob uas ua haujlwm zoo ua ke los pib lub cev tiv thaiv kab mob tiv thaiv kab mob. Naive T hlwb yog T hlwb uas txawv thiab tau raug tso tawm los ntawm thymus tab sis tseem tsis tau ntsib lawv cov antigens sib xws, thaum effector T hlwb yog T hlwb uas tsim los ntawm naive T hlwb tom qab lawv tau ntsib lawv cov antigens sib xws. Yog li, qhov no qhia txog qhov sib txawv ntawm naive thiab effector T cells.
