Qhov sib txawv tseem ceeb ntawm PTH thiab TSH yog PTH yog peptide hormone secreted los ntawm lub caj pas parathyroid uas tswj cov ntshav calcium ion concentration los ntawm nws cov nyhuv ntawm pob txha, ob lub raum, thiab txoj hnyuv, thaum TSH yog peptide hormone secreted los ntawm lub pituitary caj pas, uas txhawb cov thyroid caj pas los tsim thyroxine thiab triiodothyronine txhawm rau txhawm rau txhawb cov metabolism hauv yuav luag txhua cov ntaub so ntswg hauv lub cev.
Peptide cov tshuaj hormones yog cov tshuaj hormones uas nws cov molecules yog peptides hauv cov xwm txheej. Cov tshuaj hormones no muaj kev cuam tshuam rau cov kab mob endocrine ntawm cov tsiaj, suav nrog tib neeg. Thaum ib qho tshuaj peptide khi rau ib qho receptor nyob rau saum npoo ntawm cov hlwb, tus xa xov thib ob tshwm hauv cytoplasm. Qhov no ua rau cov teeb liab transduction uas ua rau cov txheej txheem ntawm tes. PTH thiab TSH yog ob hom peptide hormones.
PTH yog dab tsi?
Parathyroid hormone (PTH) yog peptide hormone secreted los ntawm lub caj pas parathyroid. Nws tswj cov ntshav calcium ion concentration los ntawm nws cov nyhuv ntawm cov pob txha, lub raum, thiab txoj hnyuv. PTH feem ntau cuam tshuam rau pob txha remodelling, uas yog txheej txheem uas cov pob txha cov ntaub so ntswg hloov pauv thiab rov tsim dua lub sijhawm. Cov tshuaj no tau tso tawm los ntawm cov lus teb rau cov ntshav ntshav qis calcium (Ca2+) qib. PTH nkoos osteoclast kev ua si nyob rau hauv cov pob txha matrix thiaj li yuav tso tawm ntau ionic calcium rau hauv cov ntshav, uas elevates cov qib calcium uas qis. Yog li ntawd, PTH zoo li tus yuam sij uas qhib lub tsev txhab nyiaj kom tshem tawm cov calcium.
Daim duab 01: PTH
PTH feem ntau zais los ntawm cov hlwb tseem ceeb ntawm cov qog parathyroid. Qhov no polypeptide muaj 84 amino acids. Nws yog prohormone ntawm molecular hnyav nyob ib ncig ntawm 9500 Da. Qhov kev txiav txim ntawm PTH yog tawm tsam cov tshuaj hormone calcitonin. Muaj ob hom receptors rau cov tshuaj no: parathyroid hormone 1 receptor thiab parathyroid hormone 2 receptor. Parathyroid hormone 1 receptors muaj nyob rau theem siab ntawm cov hlwb ntawm cov pob txha thiab lub raum, thaum parathyroid hormone 2 receptors muaj nyob rau theem siab ntawm cov hlwb ntawm lub hauv nruab nrab lub paj hlwb, pancreas, testes, thiab placenta.
YTSH is What?
Thyroid-stimulating hormone (TSH) yog peptide hormone secreted los ntawm pituitary caj pas. TSH txhawb nqa cov thyroid caj pas los tsim thyroxine (T4) thiab triiodothyronine (T4) txhawm rau txhawb cov metabolism hauv yuav luag txhua cov ntaub so ntswg hauv lub cev. TSH yog glycoprotein. Nws yog tsim los ntawm thyrotrope hlwb nyob rau hauv lub anterior pituitary caj pas. TSH feem ntau tswj hwm kev ua haujlwm endocrine ntawm cov thyroid.
Figure 02: TSH
TSH hormone muaj ob subunits: α subunit thiab β subunit. α subunit tau xav tias yog thaj tsam effector lub luag haujlwm rau kev txhawb nqa ntawm adenylate cyclise. Nws muaj 92 amino acids. β subunit yog tshwj xeeb rau TSH, thiab nws txiav txim siab qhov tshwj xeeb receptor ntawm TSH. Nws muaj 118 amino acids. Tsis tas li ntawd, TSH receptor feem ntau pom nyob rau hauv cov thyroid follicular cells.
Dab tsi yog qhov zoo sib xws ntawm PTH thiab TSH?
- PTH thiab TSH yog ob hom peptide hormones.
- Ob leeg cov tshuaj hormones yog tsim los ntawm cov amino acids.
- Lawv muaj cov receptors tshwj xeeb hauv lub cev.
- Lawv ua haujlwm tseem ceeb hauv endocrine hauv lub cev.
Dab tsi ntawm PTH thiab TSH?
PTH yog peptide hormone secreted los ntawm lub caj pas parathyroid los tswj cov ntshav calcium ion concentration los ntawm nws cov nyhuv ntawm cov pob txha, lub raum, thiab txoj hnyuv, thaum TSH yog peptide hormone secreted los ntawm lub caj pas pituitary, uas txhawb cov thyroid caj pas. tsim thyroxine (T4) thiab triiodothyronine (T4) txhawm rau txhawb cov metabolism hauv yuav luag txhua cov ntaub so ntswg hauv lub cev. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm PTH thiab TSH. Tsis tas li ntawd, PTH yog tsim los ntawm cov hlwb tseem ceeb ntawm cov qog nqaij hlav parathyroid, thaum TSH yog tsim los ntawm thyrotrope hlwb nyob rau hauv lub caj pas anterior pituitary.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm PTH thiab TSH hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – PTH vs TSH
Peptide cov tshuaj hormones yog cov tshuaj hormones tsim los ntawm cov amino acids. Lawv yog peptides nyob rau hauv cov xwm. PTH thiab TSH yog ob hom peptide hormones. PTH yog peptide hormone secreted los ntawm lub caj pas parathyroid. Nws tswj cov ntshav calcium ion concentration los ntawm nws cov nyhuv ntawm cov pob txha, lub raum, thiab txoj hnyuv. TSH yog peptide hormone secreted los ntawm pituitary caj pas. Nws txhawb nqa cov thyroid caj pas los tsim thyroxine (T4) thiab triiodothyronine (T4) txhawm rau txhawb cov metabolism hauv yuav luag txhua cov ntaub so ntswg hauv lub cev. Yog li, qhov no qhia txog qhov sib txawv ntawm PTH thiab TSH.
