Qhov sib txawv tseem ceeb ntawm cytoplasmic thiab axonemal dynein yog tias cytoplasmic dynein muaj nyob rau hauv tag nrho cov tsiaj hlwb thiab cov nroj tsuag hlwb, thaum axonemal dynein tsuas yog pom hauv cov hlwb uas muaj cov qauv zoo li cilia thiab flagella.
Dynein yog lub cev muaj zog protein uas txav raws microtubules hauv cov hlwb. Nws ib txwm hloov cov tshuaj siv hluav taws xob khaws cia hauv ATP rau kev ua haujlwm txhua yam. Dynein thauj ntau lub cellular cargos, muab kev quab yuam thiab kev hloov pauv tseem ceeb hauv kev faib tawm ntawm tes xws li mitosis, thiab tsav cov kev sib tw ntawm cov qauv xws li eukaryotic cilia thiab flagella. Muaj ob hom dynein proteins: cytoplasmic thiab axonemal dynein.
Cytoplasmic Dynein yog dab tsi?
Cytoplasmic dynein yog ib hom dynein protein uas pom nyob rau hauv tag nrho cov tsiaj hlwb thiab cov nroj tsuag hlwb. Nws yog qhov loj microtubule-raws li lub cev muaj zog protein rau cov khoom thauj mus rau microtubule rho tawm kawg. Cytoplasmic dynein yog ib qho loj protein complex uas muaj kaum ob subunits. Qhov hnyav molecular ntawm no protein complex yog nyob ib ncig ntawm 1.5 MDa. Cov subunits loj tshaj plaws yog cov chains hnyav (DYNCIH1, DYNC2H1), thiab lawv muaj lub taub hau thiab tus Tsov tus tw. Lub taub hau muaj lub cev muaj zog nrog microtubule khi thiab ATP hydrolysis domains uas tsim kom muaj kev txav ntawm microtubules. Lwm kaum subunits yog ob qhov nruab nrab chains (DYNC1I1, DYNC1I2), ob lub teeb nruab nrab chains (DYNC1LI, DYNC1L2), thiab ob peb lub teeb chains (DYNLL1, DYNLL2, DYNLRB1, DYNLRB2, DYNLT1, thiab DYNLT3). Cov kaum subunits no khi ncaj qha lossis tsis ncaj rau tus Tsov tus tw ntawm cov saw hnyav (lub taub hau) thiab suav nrog cov khoom thauj khoom.
Daim duab 01: Cytoplasmic Dynein
Ntxiv mus, cytoplasmic dynein ua haujlwm tsim nyog rau kev muaj sia nyob ntawm tes, xws li kev thauj organelle thiab centrosome los ua ke. Tsis tas li ntawd, cytoplasmic dynein pab txhawm rau tso Golgi complex thiab lwm yam organelles hauv lub cell. Tsis tas li ntawd, nws pab thauj cov khoom thauj uas xav tau rau kev ua haujlwm ntawm tes, xws li cov hlwv uas ua los ntawm endoplasmic reticulum, endosomes, thiab lysosomes.
Axonemal Dynein yog dab tsi?
Axonemal dynein yog ib hom dynein motor protein tsuas pom nyob rau hauv cov hlwb uas muaj cov qauv zoo li cilia thiab flagella. Axonemal dynein yog thawj dynein uas tau pom nyob rau hauv 1963. Structurally, Axonemal dynein muaj 8 subunits. Nws muaj peb txoj hlua hnyav uas tsis zoo ib yam (DNAH1, DNAH2, thiab DNAH3). Txhua cov saw hnyav muaj lub cev lub cev muaj zog nrog cov qauv ntawm lub khob noom cookie, lub coiled-coil "stalk" uas khi rau microtubule, thiab tus Tsov tus tw txuas ntxiv uas txuas rau cov microtubule nyob sib ze ntawm tib axoneme. Lwm cov subunits suav nrog cov saw nruab nrab (DNAI1 thiab DNAI2), cov saw teeb nruab nrab (DNALI1), thiab cov saw teeb (DNAL1 thiab DNAL4).
Daim duab 02: Axonemal Dynein
Ntxiv mus, dynein ua rau zawv zawg ntawm microtubules hauv axonemes ntawm cilia thiab flagella. Nws tsuas yog pom nyob rau hauv cov hlwb uas muaj cov qauv no. Tsis tas li ntawd, kev tswj hwm ntawm axonemal dynein kev ua si yog qhov tseem ceeb heev rau flagella yeej nquag thiab yoj daim ntawv ntawm cilia. Cov kev cai no yog tsim los ntawm phosphorylation, redox cov tshuaj tiv thaiv, thiab calcium.
Dab tsi yog qhov zoo sib xws ntawm Cytoplasmic thiab Axonemal Dynein?
- Cytoplasmic thiab axonemal dynein yog ob hom dynein proteins.
- Ob leeg yog lub cev muaj zog cov protein uas txav mus raws microtubules hauv cov hlwb.
- ob leeg yog tsim los ntawm cov amino acids.
- Structurally, ob lub dynein muaj subunits.
- Lawv ua haujlwm tseem ceeb hauv cell.
Qhov txawv ntawm Cytoplasmic thiab Axonemal Dynein yog dab tsi?
Cytoplasmic dynein pom muaj nyob rau hauv txhua lub hlwb tsiaj thiab tejzaum nws nyob rau hauv cov nroj tsuag hlwb ib yam nkaus, thaum axonemal dynein tsuas yog pom nyob rau hauv cov hlwb uas muaj cov qauv zoo li cilia thiab flagella. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cytoplasmic thiab axonemal dynein.
Cov hauv qab no qhia txog qhov sib txawv ntawm cytoplasmic thiab axonemal dynein hauv daim ntawv qhia rau ib sab ntawm kev sib piv.
Summary – Cytoplasmic vs Axonemal Dynein
Cytoplasmic thiab axonemal dynein yog ob hom dynein proteins. Cytoplasmic dynein muaj nyob rau hauv tag nrho cov tsiaj hlwb thiab tejzaum nws nyob rau hauv cov nroj tsuag hlwb ib yam nkaus, thaum axonemal dynein tsuas yog pom nyob rau hauv cov hlwb uas muaj cov qauv zoo li cilia thiab flagella. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm cytoplasmic thiab axonemal dynein.
