Qhov sib txawv tseem ceeb ntawm Azathioprine thiab 6-mercaptopurine yog Azathioprine ua haujlwm los ntawm inhibiting purine synthesis, whereas 6-mercaptopurine ua haujlwm los ntawm kev cuam tshuam nrog cov txheej txheem metabolic hauv hlwb kom cuam tshuam DNA thiab RNA synthesis.
Azathioprine yog cov tshuaj tiv thaiv kab mob uas muag hauv lub npe Imuran thaum 6-mercaptopurine yog cov tshuaj muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav thiab kab mob autoimmune.
Azathioprine yog dab tsi?
Azathioprine yog cov tshuaj tiv thaiv kab mob uas muag hauv qab lub npe Imuran. Nws yog abbreviated li AZA. Cov tshuaj no tuaj yeem siv los kho mob rheumatoid mob caj dab, granulomatosis nrog polyangiitis, Crohn tus kab mob, ulcerative colitis thiab systemic lupus erythematosus, hloov raum rau kev tiv thaiv kev tsis lees paub. Cov tshuaj no yog noj los yog txhaj rau hauv cov hlab ntsha.
Daim duab 01: Cov Qauv Tshuaj ntawm Azathioprine
Muaj qee qhov kev phiv ntawm Azathioprine: pob txha pob txha thiab ntuav. Txawm li cas los xij, kev tiv thaiv pob txha pob txha yog tshwm sim rau cov neeg uas muaj caj ces tsis muaj peev xwm ntawm enzyme thiopurine S-methyltransferase. Nws tuaj yeem muaj qee qhov cuam tshuam loj heev, xws li mob qog noj ntshav. Yog noj thaum cev xeeb tub, nws tuaj yeem ua mob rau tus menyuam.
Lub bioavailability ntawm Azathioprine yog li 60%. Txawm li cas los xij, bioavailability nyob nruab nrab ntawm 30 txog 90% hauv cov neeg mob. Qhov no yog vim hais tias cov tshuaj no yog ib feem inactivated nyob rau hauv lub siab. Lub peev xwm ntawm cov protein khi ntawm cov tshuaj no yog nyob ib ncig ntawm 20 - 30%. Nws cov metabolism tshwm sim activated non-enzymatically thiab deactivated los ntawm xanthine oxidase. Kev tshem tawm ib nrab-lub neej ntawm Azathioprine yog li 26 - 80 teev. Cov tshuaj tso tawm los ntawm lub raum.
Thaum xav txog cov txheej txheem ntawm kev ua ntawm cov tshuaj no, nws tuaj yeem inhibit purine synthesis. Feem ntau, purine yuav tsum tau tsim DNA thiab RNA. Yog li, inhibition ntawm purine tuaj yeem ua rau txo qis ntawm DNA thiab RNA, uas yuav tsum tau ua rau kev tsim cov qe ntshav dawb. Qhov no, nyob rau hauv lem, ua rau immunosuppression.
6-Mercaptopurine yog dab tsi?
6-mercaptopurine yog cov tshuaj muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav thiab kab mob autoimmune. Cov tshuaj no yog muag raws li lub npe Purinethol. Qhov tseem ceeb tshaj plaws, 6-mercaptopurine muaj txiaj ntsig zoo hauv kev kho mob qog ntshav qog ntshav qog ntshav, mob ntshav qab zib, thiab mob plab hnyuv.
Daim duab 02: Cov Qauv Tshuaj ntawm 6-Mercaptopurine
Muaj qee qhov kev mob tshwm sim xws li mob pob txha pob txha, mob siab rau, ntuav, thiab tsis qab los noj mov. Txawm li cas los xij, tuaj yeem muaj qee qhov kev mob tshwm sim hnyav, xws li mob qog noj ntshav thiab mob pancreatitis. Ntxiv mus, kev siv cov tshuaj no thaum cev xeeb tub tuaj yeem ua rau muaj kev phom sij rau tus menyuam.
Lub bioavailability ntawm 6-mercaptopurine tuaj yeem nyob nruab nrab ntawm 5 - 37%. Metabolism ntawm cov tshuaj no tshwm sim nyob rau hauv lub xub ntiag ntawm xanthine oxidase. Kev tshem tawm ib nrab-lub neej ntawm cov tshuaj no yog li 60 mus rau 120 feeb. Kev tso tawm tshwm sim hauv lub raum.
Qhov txawv ntawm Azathioprine thiab 6-Mercaptopurine yog dab tsi?
Azathioprine yog cov tshuaj tiv thaiv kab mob uas muag hauv lub npe Imuran thaum 6-mercaptopurine yog cov tshuaj muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav thiab kab mob autoimmune. Qhov sib txawv tseem ceeb ntawm Azathioprine thiab 6-mercaptopurine yog Azathioprine ua haujlwm los ntawm inhibiting purine synthesis, whereas 6-mercaptopurine ua haujlwm los ntawm kev cuam tshuam nrog cov txheej txheem metabolic hauv hlwb kom cuam tshuam DNA thiab RNA synthesis. Tsis tas li ntawd, cov pob txha pob txha thiab ntuav yog cov kev mob tshwm sim ntawm Azathioprine thaum cov pob txha lov, lub siab toxicity, ntuav, thiab tsis qab los noj mov yog ib co kev phiv ntawm 6-mercaptopurine.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm Azathioprine thiab 6-mercaptopurine hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Azathioprine vs 6-Mercaptopurine
Azathioprine thiab 6-mercaptopurine yog cov tshuaj tseem ceeb los kho mob qog noj ntshav thiab kab mob ntsig txog. Qhov sib txawv tseem ceeb ntawm Azathioprine thiab 6-mercaptopurine yog Azathioprine ua haujlwm los ntawm inhibiting purine synthesis, whereas 6-mercaptopurine ua haujlwm los ntawm kev cuam tshuam nrog cov txheej txheem metabolic hauv cov hlwb kom cuam tshuam DNA thiab RNA synthesis.
