Qhov sib txawv tseem ceeb ntawm CD55 thiab CD59 yog CD55 yog cov protein uas tswj cov txheej txheem ntxiv los ntawm inhibiting aggregation ntawm C3 convertases ntawm classical thiab lwm txoj hauv kev thiab tsim ua tiav membrane nres complexes, thaum CD59 yog ib qho protein uas tswj cov txheej txheem. ua kom tiav qhov system los ntawm kev tiv thaiv C9 los ntawm polymerizing thiab tsim ua tiav membrane nres complexes.
Complement membrane nres complex yog ib qho nyuaj ntawm cov protein tsim nyob rau saum npoo ntawm cov kab mob cell membrane raws li kev ua ntawm kev ua kom tiav ntawm tus tswv tsev. Kev tsim ntawm cov khoom siv sib xyaw ua ke ua rau lub cev ua rau cov kab mob cell lysis. Muaj cov molecules sib txawv uas tuaj yeem tswj hwm cov txheej txheem ntxiv thiab tsim kom muaj kev sib xyaw ua ke ntawm cov membrane nres complex. Yog li ntawd, CD55 thiab CD59 yog ob lub proteins uas tswj cov txheej txheem ntxiv los ntawm inhibiting qhov tsim ntawm cov khoom sib xyaw ua ke ntawm kev sib koom ua ke.
CD55 yog dab tsi?
CD55, tseem hu ua ntxiv kev lwj-ua kom nrawm nrawm lossis DAF, yog cov protein uas tswj hwm cov txheej txheem ntxiv los ntawm inhibiting aggregation ntawm C3 convertases ntawm cov classical thiab lwm txoj kev thiab tsim ua kom tiav membrane nres complex. CD55 tswj cov txheej txheem ntxiv rau ntawm lub xov tooj ntawm tes. Nws feem ntau lees paub C4b thiab C3b cov seem tsim thaum lub sij hawm ua kom C4 (classical thiab lwm txoj kev) thiab C3 (alternative pathway). Kev sib cuam tshuam ntawm CD55 nrog C4b ntawm classical thiab lectin txoj kev cuam tshuam nrog kev hloov pauv ntawm C2 rau C2b, yog li tiv thaiv kev tsim ntawm C4b2a (C3 convertase hauv classical thiab lectin pathway). Ntawm qhov tod tes, thaum CD55 cuam tshuam nrog C3b ntawm lwm txoj hauv kev, nws cuam tshuam nrog kev hloov pauv ntawm yam B rau Bb los ntawm yam D. Yog li, qhov no tiv thaiv kev tsim ntawm C3bBb (C3 convertase nyob rau hauv lwm txoj kev). Yog li ntawd, CD55 yeej inactivates C3 convertases, uas indirectly tiv thaiv kev tsim ntawm daim nyias nyias nres complex.
Daim duab 01: CD55
Tsis tas li ntawd, qhov glycoprotein no tau encoded los ntawm CD55 noob hauv tib neeg. CD55 kuj tseem faib dav ntawm cov hematopoietic thiab tsis-hematopoietic hlwb. Tsis tas li ntawd, nws kuj yog ib qho kev txiav txim siab rau Cromer pawg ntshav.
CD59 yog dab tsi?
CD59 yog cov protein uas tswj hwm cov txheej txheem ntxiv los ntawm kev tiv thaiv C9 los ntawm polymerizing thiab tsim kom muaj kev sib txuas ntawm cov membrane nres complex. Nws tseem hu ua MAC-inhibitory protein (MAC-IP), membrane inhibitor ntawm reactive lysis (MIRL), los yog tiv thaiv. CD59 yog glycoprotein, thiab nws yog encoded los ntawm CD59 noob hauv tib neeg. Nws yog LU domain protein. Ntxiv mus, CD59 belongs rau LY6 / uPAR / alpha-neurotoxin protein tsev neeg.
Daim duab 02: CD59
CD59 txuas rau cov tswv tsev cell los ntawm glycophosphatidylinositol (GPI) thauj tog rau nkoj. Nquag, thaum ntxiv kev ua kom tiav ua rau kev tso tawm ntawm C5b678 ntawm cov tswv tsev cell, CD59 tuaj yeem tiv thaiv cov polymerizing thiab tsim ua kom tiav cov membrane nres complexes. CD59 kuj tseem tuaj yeem taw qhia lub xov tooj ntawm tes los ua cov kev ntsuas nquag xws li endocytosis ntawm CD59-CD9 complex. Tsis tas li ntawd, cov kev hloov pauv cuam tshuam rau GPI thauj tog rau nkoj txo qhov kev qhia ntawm CD59, uas ua rau muaj tus kab mob hu ua paroxysmal nocturnal hemoglobinuria.
Dab tsi zoo sib xws ntawm CD55 thiab CD59?
- CD55 thiab CD59 yog ob lub proteins uas tswj cov txheej txheem ntxiv los ntawm inhibiting qhov tsim ntawm kev sib txuas ntawm cov membrane nres complexes.
- Ob leeg yog glycoproteins.
- Kev hloov pauv cuam tshuam rau GPI thauj tog rau nkoj txo qhov kev qhia ntawm CD55 thiab CD59, uas ua rau muaj kab mob hu ua paroxysmal nocturnal hemoglobinuria.
- Lawv tseem ceeb heev rau kev tswj hwm lub cev tiv thaiv kab mob.
Qhov txawv ntawm CD55 thiab CD59 yog dab tsi?
CD55 yog cov protein uas tswj hwm lub zog ntxiv los ntawm inhibiting aggregation ntawm C3 convertases ntawm classical thiab lwm txoj kev thiab tsim complement membrane nres complexes, thaum CD59 yog ib tug protein uas tswj lub complement system los ntawm kev tiv thaiv C9 los ntawm polymerizing thiab tsim. complement membrane nres complex. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm CD55 thiab CD59. Tsis tas li ntawd, CD55 yog encoded los ntawm CD55 noob hauv tib neeg, thaum CD59 yog encoded los ntawm CD59 noob hauv tib neeg.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm CD55 thiab CD59 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – CD55 vs CD59
CD55 thiab CD59 yog ob glycoproteins. CD55 tswj cov txheej txheem ntxiv los ntawm inhibiting aggregation ntawm C3 convertases ntawm cov txheej txheem classical thiab lwm txoj hauv kev thiab ua kom tiav cov membrane nres complex. Ntawm qhov tod tes, CD59 tswj cov txheej txheem ntxiv los ntawm kev tiv thaiv C9 los ntawm polymerizing thiab tsim kom muaj qhov sib ntxiv ntawm daim nyias nyias. Yog li, nws yog qhov sib txawv tseem ceeb ntawm CD55 thiab CD59.
