Qhov sib txawv tseem ceeb ntawm G6PD thiab mob qog noj ntshav yog G6PD (glucose 6 phosphate dehydrogenase) yog ib qho enzyme uas tiv thaiv cov qe ntshav liab los ntawm hemolysis thaum lub mob qog nqaij hlav yog qhov txawv txav ntawm cov qe ntshav liab uas ua rau cov ntshav liab liab. cov ntshav.
Haemolytic anemia yog ntshav tsis txaus. Hauv qhov xwm txheej no, cov qe ntshav liab raug rhuav tshem sai dua li lawv tau ua ke. Haemolysis yog hais txog kev puas tsuaj ntawm cov qe ntshav liab. Lub luag haujlwm ntawm cov qe ntshav liab yog nqa oxygen los ntawm lub cev. Yog li ntawd, yog tias tib neeg muaj cov qe ntshav liab qis, lawv yuav raug kev txom nyem los ntawm anemia. Cov mob ntshav qab zib no tuaj yeem tau txais los yog tau txais. Yog li ntawd, G6PD thiab mob qog noj ntshav yog ob nqe lus hais txog hemolysis.
G6PD yog dab tsi?
G6PD (glucose 6 phosphate dehydrogenase) yog ib qho enzyme uas tiv thaiv cov qe ntshav liab los ntawm hemolysis. G6PD yog dav faib rau ntau hom, zoo li cov kab mob rau tib neeg. Qhov enzyme no feem ntau yog ib qho dimer uas muaj ob lub monomers zoo tib yam. Glucose 6 phosphate yog lub substrate uas txhawb nqa cov piam thaj 6 phosphate dehydrogenase.
Cov enzyme no koom nrog hauv pentose phosphate metabolic txoj hauv kev uas muab kev txo qis zog rau cov hlwb. Lub luag haujlwm ntawm cov enzyme no yog txo NADP rau NADPH thaum oxidizing qabzib 6 phosphate. NADPH tswj hwm qib glutathione hauv cov qe ntshav liab. Glutathione tiv thaiv cov hlwb tiv thaiv oxidative puas los ntawm cov tebchaw xws li hydrogen peroxide. Yog li, feem ntau X txuas caj ces tsis muaj peev xwm ntawm G6PD ua rau tsis muaj kev tiv thaiv kab mob haemolytic anemia hauv tib neeg.
Daim duab 01: G6PD
G6PD enzyme deficiency feem ntau cuam tshuam rau txiv neej. Glucose 6 phosphate dehydrogenase tsis muaj peev xwm feem ntau ua rau cov tsos mob xws li daj ntseg, daj ntawm daim tawv nqaij thiab qhov muag dawb, tso zis tsaus, qaug zog, ua pa luv thiab lub plawv dhia ceev. Tsis tas li ntawd, cov neeg uas muaj cov piam thaj 6 phosphate dehydrogenase deficiency tuaj yeem muaj cov kab mob haemolytic anemia vim yog kab mob yooj yim, noj cov taum fava lossis noj qee yam tshuaj xws li tshuaj tua kab mob, tshuaj tua kab mob, lossis tshuaj tua kab mob. Kev kho mob rau cov kab mob caj ces no muaj xws li tshem tawm qhov tshwm sim uas ua rau cov tsos mob ib txwm muaj. Kev siv ntshav kuj tuaj yeem ua rau cov ntshav tsis txaus. Txawm li cas los xij, ntau tus neeg uas muaj kab mob caj ces yeej tsis muaj cov tsos mob tshwm sim thiab feem ntau tsis paub txog tus mob no.
Sickle Cell yog dab tsi?
Sickle cell yog ib qho txawv txav ntawm cov qe ntshav liab uas ua rau hemolysis ntawm cov qe ntshav liab. Tus kab mob Sickle cell yog ib pab pawg ntawm cov qe ntshav liab uas tau tshwm sim. Hauv qhov xwm txheej no, tib neeg yuav tsis muaj cov qe ntshav liab txaus kom nqa oxygen thoob plaws lub cev. Tus kab mob Sickle cell feem ntau ua raws li autosomal recessive qub qub qauv. Hemoglobin yog cov protein hauv cov qe ntshav liab. Hemoglobin muaj plaub subunits: ob alpha globin subunits thiab ob beta globin subunits.
Daim duab 02: Sickle Cell
Nyob rau hauv cov kab mob mob qog noj ntshav, kev hloov pauv hauv HBB cov noob uas tsim cov beta globin subunits ntawm hemoglobin hloov cov qe ntshav liab los ntawm biconcave mus rau cov kab mob. Qhov kev hloov pauv no yog ib qho kev hloov pauv nucleotide uas hloov cov amino acid hauv 6 thtxoj haujlwm beta globin protein los ntawm glutamine rau valine. Yog li ntawd, cov kab mob kis kab mob ua rau haemolysis thiab ua rau cov neeg mob ntshav qab zib. Cov tsos mob ntawm tus kab mob kis kab mob yog anemia, ntu ntawm qhov mob, nquag kis kab mob, ncua kev loj hlob, teeb meem tsis pom kev, daj tint nyob rau hauv daim tawv nqaij thiab lwm yam. Tsis tas li ntawd, kev kho mob rau tus mob no feem ntau yog siv los ntshav. Tab sis kev hloov cov pob txha pob txha yog ib qho kev daws teeb meem tas mus li.
Dab tsi zoo sib xws ntawm G6PD thiab Sickle Cell?
- G6PD thiab mob qog noj ntshav yog ob nqe lus ntsig txog hemolysis.
- Ob leeg yog kev txhawj xeeb tseem ceeb hauv cov neeg mob uas muaj hemolytic anemia.
- Lawv yog yam muaj txiaj ntsig los txiav txim siab ua haujlwm ntawm cov qe ntshav liab.
- Lawv ob leeg cuam tshuam nrog cov kab mob.
Qhov txawv ntawm G6PD thiab Sickle Cell yog dab tsi?
G6PD yog ib qho enzyme uas tiv thaiv cov qe ntshav liab los ntawm haemolysis thaum lub hlwb mob yog ib qho txawv txav ntawm cov qe ntshav liab uas ua rau haemolysis ntawm cov qe ntshav liab. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm G6PD thiab mob qog noj ntshav. Tsis tas li ntawd, G6PD tsis muaj peev xwm ua rau haemolytic anemia, thaum lub sij hawm ntau dhau ntawm cov kab mob qog ua rau haemolytic anemia.
Cov hauv qab no infographic teev qhov sib txawv ntawm G6PD thiab cov xov tooj ntawm tes hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – G6PD vs Sickle Cell
Hauv kev tshawb fawb tsis ntev los no, nws tau txheeb xyuas tias cov neeg mob uas muaj kab mob qog nqaij hlav (SCD) muaj ntau dua rau haemolysis vim cov qe ntshav liab thiab yog tias lawv tsis muaj G6PD enzyme. G6PD yog ib qho enzyme uas tiv thaiv cov qe ntshav liab los ntawm hemolysis. Qhov sib txawv tseem ceeb ntawm G6PD thiab mob qog noj ntshav yog G6PD yog ib qho enzyme uas tiv thaiv cov qe ntshav liab los ntawm haemolysis thaum mob qog nqaij hlav yog qhov txawv txav ntawm cov qe ntshav liab uas ua rau haemolysis ntawm cov qe ntshav liab.
