Qhov sib txawv tseem ceeb ntawm cov tshuaj pharmacokinetics thiab pharmacodynamics yog qhov kev tshawb fawb pharmacokinetics yuav ua li cas cov kab mob cuam tshuam rau cov tshuaj thaum cov tshuaj pharmacodynamics kawm tias cov tshuaj cuam tshuam rau lub cev li cas.
Pharmacology yog kev kawm txog kev cuam tshuam ntawm cov tshuaj thiab cov kab mob. Pharmacokinetics thiab pharmacodynamics yog cov khoom tseem ceeb ntawm pharmacology. Qhov no qhia txog kev sib cuam tshuam ntawm ob qho tib si endogenous thiab exogenous tshuaj lom neeg thiab cov kab mob nyob. Ob lub pharmacokinetics thiab pharmacodynamics yog ib feem ntawm cov kev tshawb fawb loj ntawm bioanalytical molecule. Cov kev tshawb fawb no pab tshawb nrhiav thiab txhim kho cov tshuaj tshiab hauv kev lag luam kws tshuaj.
YPharmacokinetics yog dab tsi?
Pharmacokinetics kawm seb lub cev cuam tshuam li cas rau cov tshuaj. Nws piav qhia yuav ua li cas lub cev reacts rau ib tug tshwj xeeb tshuaj los yog xenobiotic tom qab nws yog muab rau ib tug kab mob. Pharmacokinetics ntawm cov tshuaj nyob ntawm ob peb yam xws li tus neeg mob lub hnub nyoog, poj niam txiv neej, lub raum ua haujlwm, tshuaj pleev ib ce thiab cov tshuaj lom neeg ntawm cov tshuaj. Cov khoom ntawm pharmacokinetics ntawm cov tshuaj muaj kev cuam tshuam los ntawm txoj kev tswj hwm thiab kev siv tshuaj. Qhov no kuj cuam tshuam rau tus nqi nqus.
Daim duab 01: Pharmacokinetics vs Pharmacodynamics
txheej txheem ntawm Pharmacokinetics
Muaj tus qauv los soj ntsuam cov txheej txheem uas tshwm sim hauv pharmacokinetics. Tus qauv tau muab faib ua tsib pawg thiab hu ua LADME scheme. LADME hais txog kev ywj pheej, kev nqus, kev faib tawm, cov metabolism thiab kev tso tawm. Liberation yog qhov tso tawm ntawm cov tshuaj los tsim cov khoom siv tshuaj zaum kawg. Absorption yog cov txheej txheem ntawm cov tshuaj los yog cov khoom nkag mus rau hauv cov hlab ntshav. Kev faib tawm yog kev faib tawm ntawm cov tshuaj lossis cov khoom siv thoob plaws hauv cov kua thiab cov ntaub so ntswg ntawm lub cev. Metabolism yog qhov kev lees paub ntawm cov khoom txawv teb chaws los ntawm lub cev thiab kev hloov pauv tsis tau ntawm cov tshuaj pib rau cov metabolites. Excretion yog tshem tawm cov khoom ntawm lub cev. Pharmacokinetics tsom xam yog tus cwj pwm los ntawm cov tshuaj concentration piv rau lub sij hawm nyob rau hauv ib koob tshuaj teb nkhaus.
Pharmacodynamics yog dab tsi?
Pharmacodynamics yog kev kawm txog biochemical thiab physiological teebmeem ntawm cov tshuaj hauv lub cev. Nws qhia txog kev sib cuam tshuam ntawm cov tshuaj nrog cov ntaub so ntswg receptors uas nyob ntawm cov cell membranes lossis hauv cov kua dej intracellular. Pharmacodynamics plays lub luag haujlwm tseem ceeb hauv kev sib raug zoo ntawm koob tshuaj. Qhov ntawd yog kev sib raug zoo ntawm cov tshuaj concentration thiab cov nyhuv. Muaj xya yam tseem ceeb ntawm cov tshuaj uas lawv ua rau lub cev. Lawv yog cov stimulating action, depressing action, blocking/antagonizing action, stabilizing kev txiav txim, sib pauv/hloov kev txiav txim, ncaj qha cov tshuaj tiv thaiv, thiab ncaj qha tshuaj lom neeg cov tshuaj tiv thaiv.
Daim duab 02: Pharmacodynamics
Ob qhov kev txhawb nqa thiab kev ntxhov siab muaj qhov ncaj qha receptor agonism thiab cov teebmeem hauv qab. Thaum lub sij hawm thaiv / antagonizing kev txiav txim, cov tshuaj khi rau lub receptor yam tsis ua kom nws. Thaum lub sij hawm stabilizing, cov tshuaj yog nruab nrab. Nws tsis ua raws li ib tug stimulant los yog kev nyuaj siab. Kev hloov pauv / hloov qhov kev txiav txim pab cov tshuaj sib sau ua ib qho chaw cia. Cov tshuaj muaj txiaj ntsig ncaj qha tiv thaiv kev puas tsuaj los ntawm cov dawb radicals, thaum cov tshuaj tiv thaiv kab mob ncaj qha ua rau kev puas tsuaj ntawm cov hlwb. Pharmacodynamics analyses yog tus cwj pwm los ntawm cov nyhuv tshuaj tiv thaiv lub sij hawm nyob rau hauv cov koob tshuaj teb nkhaus.
Dab tsi zoo sib xws ntawm Pharmacokinetics thiab Pharmacodynamics?
- Ob lub tshuaj pharmacokinetics thiab pharmacodynamics yog hais txog qhov concentration ntawm cov tshuaj hauv lub cev.
- Pharmacokinetics thiab pharmacodynamics tsom xam ua lub luag haujlwm tseem ceeb hauv kev ua kom pom cov tshuaj tiv thaiv, kwv yees cov tshuaj ntau npaum li cas, kwv yees tus nqi ntawm kev tshem tawm cov tshuaj thiab kev nqus, tshuaj xyuas cov txheeb ze bioequivalence, tus yam ntxwv sib txawv, tsim kom muaj kev nyab xeeb margins thiab cov yam ntxwv ua tau zoo thiab nkag siab txog cov concentration-zoo. kev sib raug zoo.
Qhov txawv ntawm Pharmacokinetics thiab Pharmacodynamics yog dab tsi?
Pharmacokinetics yog lub zog ntawm cov tshuaj thoob plaws hauv lub cev thiab lub cev cuam tshuam rau cov tshuaj li cas. Pharmacodynamics yog cov lus teb lom ntawm lub cev rau cov tshuaj. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm pharmacokinetics thiab pharmacodynamics. Ntxiv mus, pharmacokinetics qhia tau hais tias raug tshuaj los ntawm kev ywj pheej, nqus, faib, metabolism ad excretion. Pharmacodynamics qhia cov lus teb rau cov tshuaj los ntawm biochemical thiab molecular kev sib cuam tshuam.
Cov hauv qab no qhia txog qhov sib txawv ntawm cov tshuaj pharmacokinetics thiab pharmacodynamics hauv daim ntawv teev npe.
Summary – Pharmacokinetics vs Pharmacodynamics
Pharmacology yog kev kawm txog kev cuam tshuam ntawm cov tshuaj thiab cov kab mob. Pharmacokinetics yog txoj kev tshawb fawb txog seb lub cev cuam tshuam li cas rau cov tshuaj. Nws piav qhia yuav ua li cas lub cev reacts rau ib tug tshwj xeeb tshuaj los yog xenobiotic tom qab nws yog muab rau ib tug kab mob. Pharmacodynamics yog kev kawm txog biochemical thiab physiological teebmeem ntawm cov tshuaj ntawm lub cev. Nws qhia txog kev sib cuam tshuam ntawm cov tshuaj nrog cov ntaub so ntswg receptors uas nyob ntawm cov cell membranes lossis hauv cov kua dej intracellular. Pharmacokinetics muaj tsib lub hauv paus ntsiab lus: liberation, absorption, tis, metabolism thiab excretion. Pharmacodynamics plays lub luag haujlwm tseem ceeb hauv kev sib raug zoo ntawm koob tshuaj. Qhov ntawd yog kev sib raug zoo ntawm cov tshuaj concentration thiab cov nyhuv. Pharmacokinetics tsom xam (tshuaj concentration piv rau lub sij hawm) thiab pharmacodynamics tsom xam (tshuaj nyhuv piv rau lub sij hawm) ua raws li cov cuab yeej tseem ceeb hauv kev tshawb nrhiav thiab kev loj hlob ntawm cov tshuaj tshiab. Yog li, qhov no qhia txog qhov sib txawv ntawm pharmacokinetics thiab pharmacodynamics.
