Qhov sib txawv tseem ceeb ntawm angiogenesis thiab neovascularization yog tias angiogenesis feem ntau yog hais txog kev tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm, thaum neovascularization yog txheej txheem ntawm de Novo tsim cov hlab ntsha lossis tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm.
Angiogenesis thiab neovascularization yog ob nqe lus hais txog kev tsim cov hlab ntsha tshiab. Angiogenesis yog tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm. Neovascularization, ntawm qhov tod tes, yog lub ntuj tsim ntawm cov hlab ntsha tshiab los ntawm cov txheej txheem xws li de novo tsim cov hlab ntsha lossis tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm. Kev hloov kho cov vasculature uas twb muaj lawm los tsim cov hlab ntsha tuaj yeem piav qhia raws li hom txheej txheem neovascularization.
Angiogenesis yog dab tsi?
Angiogenesis yog hom kev tsim cov hlab ntsha tshiab tshaj plaws thaum lub sijhawm loj hlob thiab kev loj hlob. Angiogenesis tshwm sim los ntawm kev tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm. Cov txheej txheem no tshwm sim los ntawm sprouting ntawm tshiab capillaries los ntawm post-capillary venules. Nws yuav tsum muaj kev sib koom ua ke ntawm ntau cov kauj ruam. Cov txheej txheem no suav nrog ntau hom xov tooj ntawm tes koom thiab sib txuas lus.
Cov txheej txheem nyuaj no yog pib los ntawm cov lus teb hauv zos rau cov ntaub so ntswg ischemia lossis hypoxia. Nws ua rau kom paub txog cov yam ntxwv angiogenic xws li vascular endothelial kev loj hlob zoo (VEGF) thiab hypoxia-inducible yam (HIFs). Lub vascular endothelial txoj kev loj hlob yog ib qho teeb liab protein tsim los ntawm fibroblast, uas txhawb kev tsim cov hlab ntsha tshiab. Hypoxia-inducible yam tseem ceeb yog cov kev hloov pauv uas teb rau qhov txo qis hauv cov pa oxygen hauv ib puag ncig ntawm tes. Thiab, tso tawm cov xwm txheej no ua rau vasodilation thiab nce vascular permeability. Cov txheej txheem no txhawb nqa cov sprouting angiogenesis lossis intussusceptive angiogenesis.
Daim duab 01: Angiogenesis
Angiogenesis yog ib txheej txheem tseem ceeb hauv kev loj hlob thiab kev loj hlob. Nws kuj tseem pab kho qhov txhab thiab tsim cov ntaub so ntswg granulation. Txawm li cas los xij, nws tseem yog cov kauj ruam tseem ceeb rau kev hloov pauv ntawm benign cancer mus rau ib qho malignant. Cov kws tshawb fawb siv angiogenesis inhibitors hauv kev kho mob qog noj ntshav.
Neovascularization yog dab tsi?
Neovascularization yog txheej txheem ntuj tsim cov hlab ntsha tshiab hauv lub cev los ntawm ob qho tib si de novo tsim thiab cov hlab ntsha uas twb muaj lawm. Lub sij hawm vasculogenesis yog lub de novo tsim ntawm cov hlab ntsha tshiab. Qhov no feem ntau tshwm sim nyob rau hauv kev tsim embryos, tab sis nws kuj tshwm sim nrog post-natal vascularization. Neovascularization muaj peb txoj kev sib txawv: vasculogenesis, angiogenesis, thiab arteriogenesis. Angiogenesis yog hom kab mob neovascularization feem ntau pom hauv kev loj hlob thiab kev loj hlob. Cov txheej txheem ntawm kev hloov pauv hloov pauv ntawm cov vasculature uas twb muaj lawm los tsim cov hlab ntsha tawg yog hu ua arteriogenesis.
Daim duab 02: Neovascularization
Cov yam tseem ceeb loj hlob uas inhibit neovascularization suav nrog cov uas cuam tshuam cov txheej txheem ntawm endothelial cell division thiab sib txawv. Cov kev loj hlob no tuaj yeem ua raws li autocrine lossis paracrine txoj kev. Cov kev loj hlob saum toj no suav nrog kev loj hlob ntawm fibroblast, placental growth factor, insulin-zoo li kev loj hlob zoo, kev loj hlob ntawm hepatocyte thiab platelet-derived endothelial kev loj hlob.
Dab tsi zoo sib xws ntawm Angiogenesis thiab Neovascularization?
- Lawv yog ob lub tswv yim ntawm kev tsim cov hlab ntsha tshiab.
- Ob lub tswv yim tseem ceeb heev los faib cov pa thiab cov as-ham thoob plaws hauv lub cev.
- Txoj kev loj hlob ua lub luag haujlwm tseem ceeb hauv ob txoj haujlwm
- Ob txheej txheem yuav ua rau mob qog noj ntshav thaum lawv ua txawv txav.
Qhov txawv ntawm Angiogenesis thiab Neovascularization yog dab tsi?
Angiogenesis feem ntau yog hais txog kev tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm. Hauv qhov sib piv, neovascularization yog de Novo tsim cov hlab ntsha los yog tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm angiogenesis thiab neovascularization. Tsis tas li ntawd, angiogenesis nce 2-3X nce hauv cov ntshav khiav. Hauv qhov sib piv, neovascularization nce ntau dua 20-30X nce hauv cov ntshav ntws.
Ntxiv mus, qhov kev loj hlob feem ntau koom nrog hauv angiogenesis yog vascular endothelial kev loj hlob thiab hypoxia-inducible yam, thaum loj hlob yam cuam tshuam nrog neovascularization yog fibroblast kev loj hlob, placental kev loj hlob factor, insulin zoo li kev loj hlob zoo, hepatocyte loj hlob yam. thiab platelet-derived endothelial kev loj hlob yam. Yog li, qhov no yog lwm qhov sib txawv tseem ceeb ntawm angiogenesis thiab neovascularization.
Hauv qab no yog cov npe ntawm qhov sib txawv ntawm angiogenesis thiab neovascularization nyob rau hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Angiogenesis vs Neovascularization
Angiogenesis yog hais txog kev tsim cov hlab ntsha tshiab los ntawm cov hlab ntsha uas twb muaj lawm, thaum neovascularization yog tsim los ntawm cov hlab ntsha tshiab los ntawm cov txheej txheem xws li de Novo tsim cov hlab ntsha lossis tsim cov hlab ntsha tshiab los ntawm kev ua ntej. - cov hlab ntsha uas twb muaj lawm. Qhov no kuj yog ib txoj hauv kev kho cov vasculature uas twb muaj lawm los tsim cov hlab ntsha. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm angiogenesis thiab neovascularization.
