Qhov sib txawv tseem ceeb ntawm hom I thiab hom II interferon yog hom I interferon khi nrog lub cell nto receptor hu ua interferon-α / β receptor (IFNAR) thaum hom II interferon khi nrog cov receptor tshwj xeeb hu ua IFN-γ receptor. (IFNGR) complex.
Interferons yog cytokines uas yog tsim los ntawm kev kis kab mob. Lub npe no tau muab vim tias lawv muaj peev xwm cuam tshuam nrog cov kab mob sib kis hauv cov kab mob hauv tsev. Tsis tas li ntawd, interferons ua rau muaj kev cuam tshuam ncaj qha thiab tsis ncaj thaum lub sij hawm kis kab mob, kab mob thiab fungi. Muaj ob hom interferons li hom I thiab hom II interferons raws li hom receptors. Lawv yog luv glycoproteins. Thaum tus kab mob kis mus rau cov hlwb, kev tsim cov tshuaj interferons raug ntxias. Tom qab ntawd, interferons txhawb cov synthesis ntawm antiviral proteins nyob rau hauv lub cell. Cov tshuaj tiv thaiv kab mob no inhibit qhov sib npaug ntawm cov kab mob sib kis. Qhov tsis muaj tus receptor rau interferons ua rau muaj kev cuam tshuam ntau ntxiv rau tus kab mob kis, suav nrog nce tus kab mob rov ua dua thiab txo qis kev ciaj sia.
Hom kuv Interferon yog dab tsi?
Type I interferon yog glycoprotein secreted los ntawm cov kab mob. Cov hom I interferons khi nrog cov cell nto receptors hu ua interferon-α/β receptor (IFNAR). Muaj ob hom tseem ceeb ntawm hom I interferons li IFN-α thiab IFN-β.
Daim duab 01: Hom I Interferon
Muaj 13 txog 14 subtypes ntawm hom I interferons. Lawv raug tso tawm los ntawm ntau hom cell, suav nrog lymphocytes (NK hlwb, B-cells thiab T-cells), macrophages, fibroblasts, endothelial hlwb, osteoblasts thiab lwm yam Cov noob coding rau hom I interferons nyob rau hauv chromosome 9 ntawm tib neeg.
Hom II Interferon yog dab tsi?
Hom II interferons yog chav kawm thib ob ntawm interferons uas tsim los ntawm cov neeg tua neeg ntuj (NK hlwb) thaum lub sijhawm tiv thaiv kab mob hauv lub cev. Lawv kuj tau tsim los ntawm T pab hlwb. Hom II interferons khi nrog IFN-γ receptor (IFNGR) complex.
Daim duab 02: Hom II Interferons
Tsuas muaj ib hom II interferons: IFN-γ. IFN-γ yog ib qho tseem ceeb ntawm cov tshuaj tiv thaiv kab mob hauv lub cev. Cov noob nyob rau ntawm chromosome12 code rau hom II interferons.
Dab tsi zoo sib xws ntawm Hom I thiab Hom II Interferon?
- Ob hom I thiab hom II interferons yog luv glycoproteins uas yog cytokines.
- Lawv muaj cov khoom tiv thaiv kab mob tsis ncaj.
- kis kab mob ua rau tsim cov interferons.
- Lawv kuj tuaj yeem cuam tshuam cov tshuaj tiv thaiv kab mob hauv lub cev.
- Interferons mediate signaling cascades hauv cov kab mob nyob.
Qhov txawv ntawm Hom I thiab Hom II Interferon yog dab tsi?
Raws li cov receptors lawv khi, muaj ob chav kawm ntawm interferons li hom I thiab hom II interferons. Hom I interferon khi nrog interferon-α / β receptor (IFNAR) thaum hom II interferon khi nrog IFN-γ receptor (IFNGR) complex. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm hom I thiab hom II interferon. IFN-α thiab IFN-β yog ob hom I interferon thaum IFN-γ tsuas yog hom II interferon.
Cov hauv qab no infographic tabulates ib sab ntau qhov sib txawv ntawm hom I thiab hom II interferon.
Summary – Hom I vs Hom II Interferon
Interferons yog luv glycoproteins / cytokines secreted los ntawm cov kab mob. Lawv muaj antiviral, anti-proliferative thiab immunomodulatory teebmeem. Lawv inhibit tus kab mob replication. Ntxiv mus, lawv txhim khu kev tiv thaiv kab mob. Muaj ob yam tseem ceeb ntawm interferons; hom I thiab hom II. IFN-α, thiab IFN-β yog hom I interferons thaum IFN-γ tsuas yog hom II interferon. Hom I interferon khi nrog ib qho ntawm cov cell nto receptor hu ua interferon-α / β receptor (IFNAR) thaum hom II interferon khi nrog cov receptor tshwj xeeb hu ua IFN-γ receptor (IFNGR) complex. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm hom I thiab hom II interferon.
