Key Difference- IgG vs IgE
Immunoglobulins yog ib hom globular proteins uas muaj cov qauv nyuaj uas tsim los ntawm cov kab mob nyob hauv lub cev raws li kev tiv thaiv kab mob thib ob thaum sib cuag nrog cov khoom txawv teb chaws lossis cov kab mob pathogenic. Immunoglobulins tseem hu ua cov tshuaj tiv thaiv lossis cov proteins tshwj xeeb uas tsim los rau cov tshuaj tiv thaiv. Cov proteins no yog cov circulatory proteins pom, thiab muaj tsib yam tseem ceeb ntawm lawv uas yog tsim nyob rau hauv ntau qhov chaw ntawm lub system nyob rau hauv teb rau txawv stimulants. Cov tsib chav kawm tseem ceeb yog immunoglobulin (Ig) A, G, M, E thiab D. Qhov sib txawv tseem ceeb ntawm IgG thiab IgE yog tias IgG feem ntau koom nrog kev sib ntaus sib tua tiv thaiv kab mob kab mob thiab kab mob thiab raug tsim los teb rau cov antigens tshwj xeeb tam sim no hauv tus kab mob los yog kab mob thaum Immunoglobulin E (IgE) yog tsim los ua ib qho kev tsis haum rau cov tshuaj tsis haum xws li paj ntoos, plua plav lossis qee yam zaub mov lossis tshuaj.
IgG yog dab tsi?
IgG yog hom immunoglobulin ntau tshaj plaws nyob rau hauv cov kab mob nyob. Nws yog daim ntawv tseem ceeb ntawm circulatory immunoglobulin nyob rau hauv lub cev thiab yog tib daim ntawv ntawm immunoglobulin uas muaj peev xwm hla lub placenta thiab mus txog lub fetus. IgG muaj plaub qhov subclasses vim nws txoj haujlwm dav: IgG1, IgG2, IgG3, thiab IgG4.
Daim duab 01: Cov qauv dav dav ntawm IgG
IgG muaj plaub txoj hlua polypeptide: 2 txoj hlua hnyav thiab 2 lub teeb saw, uas tau txuas ua ke los ntawm kev sib txuas ntawm cov saw hlau disulfide. Txhua cov saw hnyav muaj N-terminal variable domain (VH) thiab peb qhov chaw tas mus li (CH1, CH2, CH3), nrog rau qhov ntxiv "pob khawm" ntawm CH1 thiab CH2. Txhua lub teeb saw muaj N-terminal variable domain (VL) thiab ib qho chaw tas mus li (CL). Lub teeb saw txuas nrog VH thiab CH1 domains los tsim Fab caj npab ("Fab"=fragment antigen binding); ua haujlwm, V cheeb tsam cuam tshuam los tsim thaj tsam antigen-binding. Tsis tas li ntawd, IgG kuj tseem muaj thaj chaw tshwj xeeb uas muaj glycosylated amino acid ntawm 297th txoj haujlwm.
Ntau IgG Chav Kawm
IgG1
IgG1 yog cov subclass uas muaj ntau tshaj plaws thiab yog cov tshuaj tiv thaiv tam sim uas tsim tawm hauv lub cev thaum kis los ntawm cov kab mob lossis tus kab mob. Yog li, qhov tsis txaus ntawm IgG1 tuaj yeem ua rau cov tshuaj tiv thaiv kab mob thib ob txo qis thiab tuaj yeem ua rau muaj kev tiv thaiv kab mob tiv thaiv kab mob uas yuav ua rau muaj kab mob rov tshwm sim.
IgG2
Cov no yog tsim los teb rau cov kab mob capsular antigens. Cov tshuaj tiv thaiv no teb rau cov carbohydrate raws li antigens.
IgG3
Qhov no yog cov tshuaj tiv thaiv kab mob muaj zog uas feem ntau tsim tawm los teb rau tus kabmob kis. Cov tshuaj tiv thaiv kab mob uas tsim los teb rau cov pab pawg ntshav antigens kuj muaj nyob rau hauv chav kawm no.
IgG4
chav tshuaj tiv thaiv kab mob no yog tsim los teb rau kev kis kab mob ntev thiab tuaj yeem tsim tau los teb rau cov proteins uas tsim thaum kis kab mob.
IgE yog dab tsi?
IgE yog globular protein uas tsim los ua cov txheej txheem tiv thaiv kab mob thib ob hauv kev teb rau cov tshuaj tsis haum thiab cov tshuaj tsis haum xws li plua plav, paj ntoos, qee yam zaub mov, thiab tshuaj. IgE feem ntau pom muaj nyob rau hauv cov mucous secreting qhov chaw ntawm lub pa system, nyob rau hauv daim tawv nqaij thiab nyob rau hauv lub cev tiv thaiv kab mob xws li mast cells, basophils, thiab macrophages. Qhov tshwm sim tseem ceeb ntawm IgE cov lus teb yog cov tshuaj tiv thaiv hypersensitivity.
Daim duab 02: Cov qauv dav dav ntawm IgE
IgE tuaj yeem ua rau muaj kev tsis haum tshuaj tshwj xeeb Immunoglobulins lossis tsis ua xua tshwj xeeb immunoglobulins lossis muaj nyob hauv me me hauv cov ntshav. IgE secretions feem ntau pom nyob rau hauv kev tsis haum tshuaj uas muaj xws li nqus cov paj ntoos hmoov av los yog noj cov tshuaj allergen uas muaj cov khoom noj. Nyob rau hauv teb rau kev tsis haum tshuaj, nws ua rau kom cov secretion ntawm histamines thiab cytokines uas ua rau kom vascular permeability thiab du nqaij contraction, ua rau muaj ntau yam tsos mob.
IgG thiab IgE yog dab tsi?
- IgG thiab IgE tsim cov tshuaj tiv thaiv kab mob thib ob.
- Tshuaj meej heev.
- Ob qho tshuaj tiv thaiv muaj plaub kab txuas polypeptide; 2 cov saw hnyav thiab 2 lub teeb sawb.
Qhov txawv ntawm IgG thiab IgE yog dab tsi?
IgG vs IgE |
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| IgG yog ib qho tsim los ua lub cev tiv thaiv kab mob thib ob koom nrog kev tawm tsam cov kab mob kis kab mob thiab kab mob. | IgE yog tsim los ua lub cev tiv thaiv kab mob thib ob hauv kev teb rau cov tshuaj tsis haum thiab cov lus teb tsis haum. |
| IgG muaj ntau heev (cov ntshav concentration 10-15mg / ml). | IgE tsawg dua (cov ntshav concentration 10 - 400ng / ml). |
| faib | |
| IgG tau faib rau hauv txhua qhov chaw sab hauv thiab cov ntaub so ntswg ntxiv. | IgE tau faib rau hauv cov qog ua kua hauv lub hlwb, mast cells, basophils, macrophages. |
| Immune teb | |
| IgG teb rau cov kab mob lossis kab mob. | IgE reacts teb rau allergens. |
| Teb qeeb hauv IgG. | Teb yog nrawm hauv IgE. |
| IgG teb tau ntev. | IgE teb yog luv. |
| Persistence of Antibody | |
| IgGs is lifelong. | IgE txuas ntxiv tau ob peb lub hlis xwb. |
| Muaj peev xwm hla lub Placenta | |
| IgG tuaj yeem hla tus placenta. | IgE tsis tuaj yeem hla tus placenta. |
Summary – IgG vs IgE
Immunoglobulins yog cov tshuaj tiv thaiv hauv peb cov ntshav. Lawv yog cov loj Y zoo li cov proteins uas tawm tsam antigens. Muaj tsib hom immunoglobulins. IgG thiab IgE yog ob hom immunoglobulins. Ob leeg IgG thiab IgE yog tsim nyob rau hauv lub cev raws li kev tiv thaiv kab mob thib ob. Qhov sib txawv tseem ceeb ntawm IgG thiab IgE yog tias IgG reacts teb rau cov kab mob los yog kab mob thaum IgE reacts teb rau allergens. Lawv yog cov tshuaj tiv thaiv tshwj xeeb uas ua los ntawm kev khi rau ib qho antigen tshwj xeeb thiab tsim cov tshuaj tiv thaiv antigen complex uas koom nrog hauv kev coj ua. Kev kuaj ntshav IgG thiab IgE yog cov cuab yeej kuaj mob tseem ceeb heev uas tuaj yeem muab cov phiaj xwm tseem ceeb rau kev txhim kho lub cev tiv thaiv kab mob.
Download PDF Version of IgG vs IgE
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm IgG thiab IgE
