Qhov Tseem Ceeb Qhov txawv - Glomerulonephritis vs Nephrotic Syndrome
Ib tus mob yog ib qho kev sib txuas ntawm cov teeb meem kho mob uas qhia tias muaj qee yam kab mob lossis mob hlwb. Ob yam mob uas tau tham ntawm no yog cov kab mob raum pom nyob rau hauv kev kho mob. Qhov sib txawv tseem ceeb ntawm Glomerulonephritis thiab Nephrotic Syndrome yog qib proteinuria. Hauv nephrotic syndrome, muaj cov proteinuria loj heev nrog cov protein poob ntau dua 3.5g / hnub, tab sis hauv glomerulonephritis, tsuas muaj cov proteinuria me me uas cov protein poob txhua hnub tsawg dua 3.5g.
YGlomerulonephritis yog dab tsi?
Glomerulonephritis (nephritic syndrome) yog ib yam mob uas tshwm sim los ntawm hematuria (xws li muaj cov qe ntshav liab hauv cov zis) nrog rau lwm cov tsos mob thiab cov tsos mob xws li azotemia, oliguria thiab mob me mus rau nruab nrab kub siab.
Glomerulonephritis tuaj yeem muab faib ua ob pawg loj raws li lub sijhawm ntawm tus kabmob.
- YAcute Proliferative Glomerulonephritis
- YNpaj Progressive Glomerulonephritis
YAcute Proliferative Glomerulonephritis
Tus mob no yog tus yam ntxwv histologically tshwm sim los ntawm kev nkag mus ntawm leukocytes nrog rau kev loj hlob ntawm cov hlwb glomerular. Cov xwm txheej no tshwm sim raws li cov lus teb rau cov tshuaj tiv thaiv kab mob uas tso rau hauv lub raum parenchyma.
Qhov kev nthuav qhia ntawm tus mob glomerulonephritis yog ib tus menyuam yws yws ntawm kub taub hau, malaise, xeev siab thiab haus luam yeeb, ob peb lub lis piam tom qab tus kab mob streptococcal caj pas lossis kab mob ntawm daim tawv nqaij. Txawm hais tias nws feem ntau pom tom qab kis kab mob, nws kuj tuaj yeem yog vim tsis kis kab mob.
Pathogenesis
Exogenous lossis endogenous antigens
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khi nrog cov tshuaj tiv thaiv uas tsim tawm tsam lawv
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Antigen- tshuaj tiv thaiv kab mob complexes tau tso rau hauv cov phab ntsa glomerular capillary
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Ua rau qhov inflammatory teb
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Kev loj hlob ntawm glomerular cells thiab nkag mus ntawm leukocytes
Morphology
- Nyob rau hauv lub teeb tsom iav kom loj, hyper cellular glomeruli tuaj yeem pom.
- Globular deposits ntawm IgG thiab C3, sib sau raws glomerular hauv qab daim nyias nyias tuaj yeem pom tau siv lub tshuab ntsuas immunofluorescence.
Daim duab 01: Micrograph ntawm tus kab mob glomerulonephritis tom qab.
Kev Kho Mob
Ib feem coob ntawm cov neeg mob rov zoo tom qab kho kom raug. Ntau tus neeg mob tuaj yeem nce mus rau qhov hnyav dua, ua rau mob glomerular nephritis sai.
Kev kho mob
Txoj kev kho mob kom tswj tau cov dej thiab sodium sib npaug
Rapidly Progressive Glomerulonephritis (RPGN)
Raws li lub npe qhia, tus mob no yog tus cwj pwm los ntawm kev ua haujlwm sai thiab ua rau lub raum tsis ua haujlwm vim muaj kev puas tsuaj loj rau lub glomeruli.
Pathogenesis
Kev nce sai sai ntawm Glomerulonephritis tuaj yeem pom nyob rau hauv ntau yam kab mob xws li zoo pasture's syndrome, IgA nephropathy, Henoch Schonlein purpura thiab microscopic polyangiitis. Txawm hais tias lub pathogenesis muaj feem xyuam rau lub cev tiv thaiv kab mob, qhov tseeb mechanism ntawm tus txheej txheem tsis meej.
Morphology
Macroscopically loj, lub raum daj ntseg muaj petechial hemorrhages ntawm cortical nto tuaj yeem pom. Microscopically, qhov tseem ceeb tshaj plaws rau kev sib txawv ntawm kev loj hlob sai ntawm glomerulonephritis los ntawm lwm yam mob yog qhov muaj "Crescents" uas yog tsim los ntawm kev loj hlob ntawm parietal hlwb thiab kev tsiv teb tsaws ntawm monocytes thiab macrophages rau hauv cov ntaub so ntswg.
Clinical Course
Kev loj hlob sai ntawm glomerulonephritis tuaj yeem ua rau muaj kev phom sij rau lub neej yog tias tsis kho kom raug. Tus neeg mob tuaj yeem xaus rau qhov mob hnyav oliguria vim yog qhov tsis zoo ntawm lub raum parenchyma.
Kev kho mob
RPGN yog kho nrog cov tshuaj steroids thiab tshuaj cytotoxic.
Nephrotic Syndrome yog dab tsi?
Cov cim cim ntawm nephrotic syndrome yog qhov muaj proteinuria loj heev nrog rau txhua hnub cov proteins poob ntau dua 3.5g ua. Ntxiv nrog rau cov proteinuria loj heev, hypoalbuminemia nrog ntshav albumin qib qis dua 3g / dl, dav dav edema, hyperlipidemia thiab lipiduria kuj tuaj yeem pom.
Cov kab mob pathophysiology tom qab cov kev kho mob no tuaj yeem piav qhia siv cov ntawv qhia hauv qab no.
(Edema yog aggravated los ntawm sodium thiab dej tuav vim kev ua ntawm renin)
Muaj peb qhov chaw kho mob tseem ceeb uas tshwm sim raws li nephrotic syndrome.
Npauj npaim nephropathy
Membranous Nephropathy
Lub ntsiab lus histological feature ntawm membranous nephropathy yog qhov thickening ntawm glomerular capillary phab ntsa. Qhov no tshwm sim los ntawm kev sib sau ntawm Ig uas muaj cov nyiaj tso cia.
Membranous nephropathy feem ntau cuam tshuam nrog kev siv qee yam tshuaj xws li NSAIDS, qog nqaij hlav, thiab kab mob lupus erythematosus.
Pathogenesis
Pathogenesis txawv raws li tus mob hauv qab, tab sis kev tiv thaiv kab mob yuav luag ib txwm koom nrog.
Morphology
Nyob rau hauv lub teeb tsom iav, glomeruli tuaj yeem tshwm sim ib txwm nyob rau hauv thawj theem tab sis nrog cov kab mob sib kis tsis zoo, diffuse thickening ntawm cov phab ntsa capillary tuaj yeem pom. Hauv cov mob hnyav dua, segmental sclerosis kuj tuaj yeem tshwm sim.
Minimal Change Disease
Ib piv rau lwm yam kab mob uas tau tham ntawm no, qhov kev hloov pauv me me tuaj yeem suav tias yog ib qho kab mob tsis zoo. Ib qho tseem ceeb uas yuav tsum tau pom yog qhov tsis muaj peev xwm siv lub teeb microscopy hauv kev txheeb xyuas qhov xwm txheej no.
Morphology
Raws li yav dhau los tau hais txog glomeruli tshwm sim ib txwm nyob hauv lub teeb pom kev zoo. Lub effacement ntawm ko taw txheej txheem ntawm podocytes tuaj yeem pom tau yooj yim siv lub tshuab ntsuas hluav taws xob.
Daim duab 02: Tsawg Hloov Pathology
Focal Segmental Glomerulosclerosis (FSGS)
Hauv qhov xwm txheej no, tsis yog txhua tus glomeruli raug cuam tshuam thiab txawm tias glomerulus cuam tshuam tsuas yog ib feem ntawm qhov cuam tshuam glomerulus tau mob sclerosis. Yog vim li cas tus kab mob no hu ua focal segmental glomerulosclerosis.
Pathogenesis
Pathogenesis yog vim qee qhov kev tiv thaiv kab mob sib kis.
Morphology
Kev siv lub teeb tsom rau hauv kev txheeb xyuas ntawm FSGS tsis raug pom zoo vim tias thaum lub sijhawm pib muaj lub caij nyoog ploj mus rau thaj tsam cuam tshuam ntawm cov qauv thiab tuaj txog ntawm kev kuaj mob tsis raug.
Kev siv lub tshuab ntsuas hluav taws xob yuav pom qhov ua tau zoo ntawm cov txheej txheem ko taw ntawm podocytes nrog rau cov ntshav plasma proteins uas tau muab tso rau segmentally raws phab ntsa capillary. Cov deposits no tej zaum yuav occlude lub capillary lumen.
Kev Kho Mob Nephrotic Syndrome
Hom kev kho mob txawv raws li cov kab mob hauv qab no, kev sib kis, hnub nyoog thiab kev ua raws li cov tshuaj ntawm tus neeg mob.
Dab tsi zoo sib xws ntawm Glomerulonephritis thiab Nephrotic Syndrome?
- Nyob rau hauv ob qho tib si, proteinuria thiab edema tuaj yeem pom.
- Ob leeg cuam tshuam rau lub raum parenchyma.
Qhov txawv ntawm Glomerulonephritis thiab Nephrotic Syndrome yog dab tsi?
YGlomerulonephritis vs Nephrotic Syndrome |
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| Glomerulonephritis yog ib yam mob uas tshwm sim los ntawm hematuria nrog rau lwm cov tsos mob thiab cov tsos mob xws li azotemia, oliguria & me me mus rau nruab nrab kub siab. | Nephrotic Syndrome yog ib yam mob tshwj xeeb los ntawm cov proteinuria uas siab dua 3.5g / hnub, nrog rau lwm cov tsos mob thiab cov tsos mob xws li hypoalbuminemia, edema hyperlipidemia, thiab lipiduria. |
| Proteinuria thiab Edema | |
| Txawm hais tias muaj proteinuria thiab edema tshwm sim lawv tsis tshua hnyav. | Proteinuria thiab edema hnyav dua. |
| Qhov no feem ntau tshwm sim los ntawm kev tiv thaiv kab mob. | Ua rau muaj kev tiv thaiv kab mob thiab tsis tiv thaiv kab mob. |
| Neeg Cells | |
| cov hlwb tseem ceeb yog cov hlwb endothelial. | cov hlwb tseem ceeb koom nrog yog podocytes. |
Summary - Glomerulonephritis vs Nephrotic Syndrome
Ob leeg nephritic syndrome thiab nephrotic syndrome yog mob raum uas muaj qee yam tsos mob. Tab sis txoj kab zoo uas ua rau lawv ob lub koom haum kab mob sib txawv yog kos hla cov qib proteinuria, Yog tias cov protein poob siab dua 3.5g / hnub ces nws yog nephrotic syndrome thiab vice versa. Nws yog ib qho tseem ceeb heev rau tus kws kho mob kom nkag siab zoo txog qhov sib txawv ntawm Glomerulonephritis thiab Nephrotic Syndrome.
Download PDF Version of Glomerulonephritis vs Nephrotic Syndrome
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Glomerulonephritis thiab Nephrotic Syndrome.
