Qhov Tseem Ceeb - Kinase vs Phosphorylase
Ob qho Kinase thiab Phosphorylase yog cov enzymes uas cuam tshuam nrog phosphate txawm tias muaj qhov sib txawv ntawm lawv txoj haujlwm thiab xwm. Qhov sib txawv tseem ceeb ntawm lawv yog tias, Kinase yog ib qho enzyme uas ua rau muaj kev hloov pauv ntawm pawg phosphate los ntawm ATP molecule mus rau ib qho molecule thaum phosphorylase yog ib qho enzyme uas qhia txog pawg phosphate rau hauv cov organic molecule, tshwj xeeb tshaj yog cov piam thaj. Kab lus no yuav qhia koj txog kinase thiab phosphorylase enzymes uas cuam tshuam nrog phosphate thiab piav qhia qhov txawv ntawm kinase thiab phosphorylase yog dab tsi.
Phosphorylase yog dab tsi?
Phosphorylase tau pom los ntawm Earl W. Sutherland Jr. thaum xyoo 1930s. Cov enzymes no catalyze qhov sib ntxiv ntawm ib pab pawg phosphate los ntawm ib qho inorganic phosphate los yog phosphate + hydrogen rau cov organic molecule txais. Raws li ib qho piv txwv, glycogen phosphorylase tuaj yeem ua rau cov synthesis ntawm qabzib-1-phosphate los ntawm glucan nrog rau glycogen, starch lossis m altodextrin molecule. Cov tshuaj tiv thaiv hu ua phosphorolysis uas kuj zoo ib yam li hydrolysis. Txawm li cas los xij, qhov sib txawv tsuas yog tias nws yog phosphate, tsis yog dej molecule uas muab tso rau ntawm daim ntawv cog lus.
qauv ntawm Polynucleotide phosphorylase
Kinase yog dab tsi?
Kinase enzyme tuaj yeem ua rau kev hloov pauv ntawm phosphate pawg los ntawm lub zog siab, phosphate-dawb molecules rau cov substrates. Cov txheej txheem no raug txheeb xyuas tias yog phosphorylation thaum lub substrate tau txais ib pab pawg phosphate thiab lub zog loj ntawm ATP pub rau pab pawg phosphate. Hauv cov txheej txheem phosphorylation no, kinases ua lub luag haujlwm tseem ceeb, thiab nws yog ib feem ntawm tsev neeg loj ntawm phosphotransferases. Yog li, kinases tseem ceeb heev hauv cell metabolism, tswj cov protein, thauj cellular, thiab ntau txoj hauv kev ntawm tes.
Dihydroxyacetone kinase nyob rau hauv complex nrog ib tug non-hydrolyzable ATP analog
Qhov txawv ntawm Kinase thiab Phosphorylase yog dab tsi?
Kinase thiab Phosphorylase
Kinase: Kinase yog ib qho enzyme uas ua rau kev hloov pauv ntawm phosphate pawg los ntawm lub zog siab, phosphate-dawb molecules rau cov substrates.
Phosphorylase: Phosphorylase yog ib qho enzyme uas catalyzes ntxiv ntawm ib pawg phosphate los ntawm ib qho inorganic phosphate los yog phosphate + hydrogen rau ib qho organic molecule txais.
yam ntxwv ntawm Kinase thiab Phosphorylase
Mechanism of action
Kinase: Catalyze kis tau tus mob phosphate pawg ntawm ATP mus rau ib pawg -OH ntawm lub substrate. Li no tsim ib daim ntawv cog lus phosphate ester hauv cov khoom. Cov tshuaj tiv thaiv yog hu ua phosphorylation, thiab tag nrho cov tshuaj tiv thaiv yog sau li,
Phosphorylase: Catalyze kev taw qhia ntawm pawg phosphate rau hauv cov organic molecule. Cov tshuaj tiv thaiv yog hu ua phosphorylysis thiab tag nrho cov tshuaj tiv thaiv yog sau li,
Phosphate pub rau hauv cov tshuaj tiv thaiv kinase thiab phosphorylase enzymes
Kinase: Phosphate pawg los ntawm ATP molecule
Phosphorylase: phosphate pawg los ntawm inorganic phosphate
substrate ntawm kinase thiab phosphorylase enzymes
Kinase: Cov organic molecules xws li carbohydrate, protein lossis lipid
Phosphorylase: Organic molecule tsuas yog qabzib
Cov khoom kawg ntawm kinase thiab phosphorylase enzymes
Kinase: ADP (zog molecule) + phosphorylated substrate
Phosphorylase: Yog tias cov substrate yog qabzib nws tuaj yeem tsim cov piam thaj-1-phosphate
qauv ntawm kinase thiab phosphorylase enzymes
Kinase: Kinase yog ib qho nyuaj heev tertiary qauv protein.
Phosphorylase: Kev ua haujlwm lom neeg ntawm phosphorylase yog ib qho dimer ntawm ob qhov sib npaug ntawm cov protein. Piv txwv li, glycogen phosphorylase yog cov protein ntau, muaj 842 amino acids thiab loj ntawm 97.434 kDa. Lub glycogen phosphorylase dimer muaj ob peb ntu ntawm kev lom neeg tseem ceeb, suav nrog cov chaw catalytic, glycogen khi qhov chaw thiab cov chaw allosteric.
Kev tswj hwm ntawm kinase thiab phosphorylase enzyme
Kinase: Kinases kev ua haujlwm tau tswj hwm zoo, thiab lawv muaj kev cuam tshuam hnyav rau ntawm tes. Kinases tau qhib los yog tawm los ntawm phosphorylation, los ntawm kev khi cov protein activator lossis protein inhibitor lossis los ntawm kev tswj hwm lawv qhov chaw nyob hauv lub xov tooj ntawm tes nrog rau lawv cov substrates.
Phosphorylase: Glycogen phosphorylase yog tswj los ntawm ob qho tib si allosteric tswj thiab los ntawm phosphorylation. Cov tshuaj hormones xws li epinephrine thiab insulin tuaj yeem tswj glycogen phosphorylase.
Kev faib tawm ntawm kinase thiab phosphorylase enzymes
Kinase: Kinases tau muab faib ua pawg los ntawm cov substrate lawv ua raws li cov protein kinases, lipid kinases, thiab carbohydrate kinases.
Phosphorylase: Cov phosphorylase categorized ua ob; Glycosyltransferases thiab Nucleotidyltransferases. Piv txwv rau Glycosyltransferases yog,
- Yglycogen phosphorylase
- starch phosphorylase
- m altodextrin phosphorylase
- YPurine nucleoside phosphorylase
Piv txwv rau Nucleotidyltransferases yog,
YPolynucleotide Phosphorylase
Pathology ntawm kinase thiab phosphorylase enzymes
Kinase: Kev tswj hwm kinase kev ua haujlwm tuaj yeem ua rau mob qog noj ntshav thiab kab mob hauv tib neeg, suav nrog qee hom kab mob leukemia thiab ntau lwm yam vim tias kinases tswj ntau theem uas tswj lub voj voog ntawm tes suav nrog kev loj hlob, txav mus los, thiab tuag.
Phosphorylase: Qee qhov xwm txheej xws li glycogen cia kab mob hom V - nqaij glycogen thiab glycogen cia kab mob hom VI - daim siab glycogen, thiab lwm yam yog txuam nrog phosphorylase.
