Qhov sib txawv tseem ceeb ntawm cov tshuaj tiv thaiv polysaccharide thiab cov tshuaj tiv thaiv conjugate yog cov tshuaj tiv thaiv polysaccharide tsuas muaj cov polysaccharides dawb li antigens thaum cov tshuaj tiv thaiv conjugated muaj polysaccharides ua ke nrog cov protein molecule.
Polysaccharide thiab conjugate vaccine yog ob hom tshuaj tiv thaiv. Cov tshuaj tiv thaiv polysaccharide tsuas muaj cov tshuaj polysaccharide uas yog cov tshuaj tiv thaiv kab mob los txhawb kev tiv thaiv kab mob. Yog li ntawd, lawv ua rau lub cev tsis muaj zog tiv thaiv kab mob piv rau cov tshuaj tiv thaiv conjugate. Conjugate tshuaj tiv thaiv muaj polysaccharides conjugated rau ib qho immunogenic protein. Yog li ntawd, lawv provoke ib tug muaj zog tiv thaiv teb. Ntxiv mus, cov tshuaj tiv thaiv conjugated tsim B-cell nco thiab txhaj tshuaj mus ntev. Tam sim no, cov tshuaj tiv thaiv conjugated tau hloov pauv cov tshuaj tiv thaiv polysaccharide ntau heev.
Cov tshuaj tiv thaiv Polysaccharide yog dab tsi?
Polysaccharide tshuaj tiv thaiv muaj cov tshuaj polysaccharide ntawm cov kab mob ua cov antigen los txhawb kev tiv thaiv kab mob. Lawv yog cov tshuaj tiv thaiv tsis sib xws. Cov tshuaj tiv thaiv polysaccharide dawb no ua rau lub cev tsis muaj zog. Hauv cov menyuam yaus, cov tshuaj tiv thaiv polysaccharide yog qhov yooj yim heev los tsim cov tshuaj tiv thaiv kab mob. Qhov tseeb, lawv ua rau lub cev tsis muaj zog hauv cov menyuam yaus hnub nyoog qis dua ob xyoos (tsim muaj peev xwm tiv thaiv cov menyuam yaus hnub nyoog qis dua ob xyoos) thiab tsis txhob ua rau muaj kev tsis haum tshuaj rau txhua lub hnub nyoog.
Daim duab 01: Tshuaj Tiv Thaiv Polysaccharide
Cov lus teb uas tsim los ntawm cov tshuaj tiv thaiv polysaccharide tsis yog T cell-dependent teb. Ntxiv mus, nws tsis tsim B cell nco. Tsis tas li ntawd, cov tshuaj tiv thaiv polysaccharide qhia txog kev tiv thaiv kab mob tsawg dua tom qab txhaj tshuaj dua. Cov tshuaj tiv thaiv polysaccharide muaj rau peb kab mob: kab mob pneumococcal, kab mob meningococcal, thiab Salmonella typhi.
Cov Tshuaj Tiv Thaiv Conjugate yog dab tsi?
Cov tshuaj tiv thaiv kab mob sib txuas yog cov tshuaj tiv thaiv uas muaj cov tshuaj polysaccharides sib txuas rau cov khoom siv protein. Ntxiv nrog rau polysaccharides, lawv muaj cov tshuaj tiv thaiv kab mob. Yog li ntawd, lawv provoke ib tug muaj zog tiv thaiv teb. Cov tshuaj tiv thaiv conjugated ua rau T cell-dependent teb. Ntxiv mus, lawv tsim B cell nco thiab kev tiv thaiv ntev dua. Qhov tseem ceeb tshaj plaws, cov tshuaj tiv thaiv conjugated muaj peev xwm muab kev tiv thaiv kab mob hauv cov menyuam mos, tsis zoo li cov tshuaj tiv thaiv polysaccharide.
Daim duab 02: Cov tshuaj tiv thaiv kab mob sib xyaw yog qhov zoo rau kev tiv thaiv kab mob los ntawm cov kab mob uas muaj cov txheej txheem polysaccharide zoo li Haemophilus influenzae hom b
Cov tshuaj tiv thaiv kab mob sib txuas tsis tshua muaj peev xwm ua rau lub cev tsis muaj zog. Vim yog cov txiaj ntsig zoo, cov tshuaj tiv thaiv conjugated tam sim no tau hloov cov tshuaj tiv thaiv polysaccharide. Txawm li cas los xij, muaj ntau qhov tsis zoo ntawm cov tshuaj tiv thaiv conjugated. Lawv yog kev vam khom rau T cell teb thiab qhov me me ntawm pneumococcal serotypes.
Dab tsi zoo sib xws ntawm Polysaccharide thiab Conjugate Vaccines?
- Ob qho tshuaj tiv thaiv polysaccharide thiab tshuaj tiv thaiv kab mob tiv thaiv kab mob tiv thaiv kab mob nrog polysaccharide capsule.
- Cov tshuaj tiv thaiv no suav hais tias muaj kev nyab xeeb.
- Ob qho tshuaj tiv thaiv muaj polysaccharides ntawm cov kab mob tshuaj ntsiav ua antigens.
Qhov txawv ntawm Polysaccharide thiab Conjugate Vaccines yog dab tsi?
Cov tshuaj tiv thaiv Polysaccharide tsuas muaj cov polysaccharides dawb li antigens thaum cov tshuaj tiv thaiv kab mob muaj polysaccharides ua ke nrog cov protein molecule. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm polysaccharide thiab cov tshuaj tiv thaiv conjugated. Ntxiv mus, lwm qhov sib txawv tseem ceeb ntawm cov tshuaj tiv thaiv polysaccharide thiab conjugated yog tias cov tshuaj tiv thaiv polysaccharide tsim cov tshuaj tiv thaiv kab mob uas yog T-cell ywj siab thaum cov tshuaj tiv thaiv conjugated tsim T cell-dependent tiv thaiv kab mob.
Cov ntawv qhia hauv qab no qhia ntau qhov sib txawv ntawm cov tshuaj tiv thaiv polysaccharide thiab conjugated.
Summary – Polysaccharide vs Conjugate Vaccines
Muaj ob hom tshuaj tiv thaiv uas tsim los tiv thaiv kab mob nrog cov tshuaj ntsiav polysaccharide. Lawv yog cov tshuaj tiv thaiv polysaccharide thiab cov tshuaj tiv thaiv sib xyaw. Cov tshuaj tiv thaiv polysaccharide tsuas muaj cov dawb lossis dawb polysaccharides nkaus xwb thaum cov tshuaj tiv thaiv conjugated muaj polysaccharides conjugated nrog cov protein immunogenic. Yog li qhov no yog qhov sib txawv tseem ceeb ntawm polysaccharide thiab cov tshuaj tiv thaiv conjugated. Ntxiv mus, cov tshuaj tiv thaiv conjugated tsim T cell-dependent teb nrog kev tsim ntawm B cell nco thiab txhaj tshuaj mus ntev, tsis zoo li cov tshuaj tiv thaiv polysaccharide. Li no, cov tshuaj tiv thaiv kab mob sib txuas tau hloov pauv cov tshuaj tiv thaiv polysaccharide.
