YAcyclovir vs Valacyclovir
Acyclovir thiab Valaciclovir yog ob yam tshuaj tiv thaiv kab mob. Ob yam tshuaj no yog nyob rau tib chav kawm tshuaj. Vim tias ob qho no nyob hauv tib chav kawm, lawv cov txheej txheem ntawm kev ua haujlwm zoo sib xws. Txawm li cas los xij, lwm yam cwj pwm txawv me ntsis.
YAcyclovir
Acyclovir yog cov tshuaj tiv thaiv kab mob ua ke siv cov nucleoside rho tawm los ntawm daim txhuam cev Cryptotethya crypta. Nws muaj nyob rau hauv kev ua lag luam raws li ntau lub npe. Lub npe tshuaj ntawm acyclovir yog acycloguanosine. Acyclovir yog ib qho tshuaj uas siv ntau heev, thiab qhov qhia tau tshaj plaws yog kab mob Herpes. Nws kuj yog siv los kho tus kab mob pox thiab shingles. Nws tuaj yeem siv thaum cev xeeb tub yog tias cov txiaj ntsig zoo tshaj qhov txaus ntshai xwb.
Lub tshuab ua haujlwm ntawm acyclovir yog qhov nyuaj. Thaum cov tshuaj nkag mus rau hauv lub cev, tus kab mob enzyme hu ua thymidine kinase hloov mus rau acyclovir monophosphate. Tom qab ntawd, cellular kinase enzymes hloov nws mus rau hauv acyclovir triphosphate. Cov khoom kawg no thaiv DNA replication thiab viral reproduction. Acyclovir muaj txiaj ntsig zoo rau ntau hom kab mob herpes tsev neeg, thiab kev tiv thaiv rau cov tshuaj ua haujlwm tsis tshua muaj tshwm sim.
Acyclovir tsis yog tshuaj soluble dej. Yog li ntawd, yog hais tias noj nyob rau hauv cov ntsiav tshuaj daim ntawv tus nqi uas mus txog rau cov ntshav yog me me. Qhov no yog hu ua bioavailability tsawg. Yog li kom tau txais cov concentration siab, acyclovir yuav tsum tau muab tso rau hauv txoj hlab ntshav. Acyclovir khi nrog plasma proteins yooj yim thiab thauj mus rau txhua qhov chaw hauv lub cev. Nws tau tshem tawm ntawm lub cev sai sai. Lub neej ib nrab ntawm cov neeg laus yog li 3 teev. Ib nrab-lub neej yog lub sij hawm coj los txo cov concentration los ntawm ib nrab. Tsuas yog 1% ntawm cov neeg mob uas tau txais acyclovir muaj kev phiv tshuaj. Nws tuaj yeem ua rau xeev siab, ntuav thiab cov quav xoob feem ntau, thiab hnov lus, encephalopathy, edema, thiab mob pob qij txha hauv cov koob tshuaj ntau. Tsis tshua muaj tshwm sim Stevens Johnson syndrome, platelets tsawg, thiab poob siab.
Valacyclovir
Valacyclovir yog lwm cov tshuaj tiv thaiv kab mob sib xyaw ua ke siv ntuj L-Valine amino acid thiab muaj nyob hauv ntau lub npe. Valaciclovir yog ib qho ester ntawm acyclovir. Nws muaj bioavailability zoo dua li acyclovir. Tom qab nkag mus rau hauv lub cev esterase enzymes hloov mus rau acyclovir thiab Valine. Valacyclovir ua rau lub siab metabolism thaum nws nkag mus rau hauv lub siab, nkag mus rau hauv lub cev. Thaum nws hloov dua siab tshiab rau hauv acyclovir, cov txheej txheem ntawm kev ua haujlwm zoo ib yam li acyclovir.
Valaciclovir yog siv los kho tus kab mob Herpesvirus tsev neeg. Vim tias nws muaj ntau dua bioavailable, thaum noj qhov ncauj, nws muaj txiaj ntsig zoo dua li qhov ncauj acyclovir. Vim tias ntau cov tshuaj nkag mus rau hauv lub cev, qhov ntau ntawm cov tshuaj tiv thaiv tsis zoo yog siab dua piv rau acyclovir.
YAcyclovir vs Valacyclovir
• Acyclovir thiab valacyclovir yog ob qho tshuaj tiv thaiv kab mob.
• Acyclovir yog cov tshuaj nquag thaum valaciclovir yog cov tshuaj tiv thaiv.
• Acyclovir tau raug tshem tawm ntawm kev ncig hauv thawj kis metabolism thaum valaciclovir tau hloov mus rau hauv daim ntawv nquag thaum thawj zaug dhau metabolism.
• Valaciclovir yog bioavailable ntau dua acyclovir.
• Kev mob tshwm sim ntau dua hauv valacyclovir.
• Valacyclovir zoo dua thaum muab qhov ncauj ntau dua li acyclovir.
