Qhov Tseem Ceeb Qhov txawv - Kev sib tw vs Tsis muaj kev sib tw Inhibition
Qhov kev ua ntawm inhibitors tuaj yeem pom nyob rau hauv ob hom kev sib tw inhibitors thiab noncompetitive inhibitors raws li qhov chaw ntawm cov enzyme qhov twg cov inhibitor khi. Qhov sib txawv tseem ceeb ntawm kev sib tw inhibition thiab noncompetitive inhibition yog tias nyob rau hauv kev sib tw inhibition, khi ntawm ib qho inhibitor tiv thaiv kev khi ntawm lub hom phiaj molecule nrog lub active site ntawm lub enzyme whereas, nyob rau hauv noncompetitive inhibition, ib tug inhibitor txo cov kev ua ntawm ib tug enzyme.
Ib qho enzyme yog ib qho macromolecule uas tuaj yeem ua raws li cov khoom siv roj ntsha. Enzymes muaj thaj chaw hu ua active sites. Qhov chaw nquag ntawm ib qho enzyme yog qhov chaw uas lub hom phiaj molecule khi. Cov molecule no hu ua substrate. Lub substrate khi nrog qhov chaw nquag thiab ua rau muaj tshuaj lom neeg. Qhov no muab qhov siab tshaj plaws tawm los ntawm lub sijhawm luv luv. Cov enzyme kuj tseem tuaj yeem siv thiab rov siv dua. Inhibitors yog cov tebchaw uas tuaj yeem tiv thaiv cov substrates los ntawm kev nkag mus rau qee yam tshuaj tiv thaiv.
Kev Sib Tw Sib Tw yog dab tsi?
Kev sib tw inhibition yog ib hom enzyme inhibition uas ib qho inhibitor khi rau cov chaw nquag ntawm cov enzyme, tiv thaiv cov substrate los ntawm kev khi rau cov enzyme. Qhov chaw nquag raug thaiv los ntawm inhibitor, yog li tsis muaj qhov chaw rau lub substrate los khi rau cov enzyme.
Nyob rau hauv hom inhibition no, cov inhibitors uas khi rau cov chaw nquag muaj xws li cov duab ntawm cov substrate molecules (yog tias tsis yog, cov inhibitors tsis tuaj yeem khi nrog rau qhov chaw nquag vim tias cov duab ntawm qhov chaw nquag tsis haum. cov duab ntawm lub substrate). Yog li, enzyme active site tsis tuaj yeem khi nrog ob qho tib si inhibitor thiab substrate tib lub sijhawm. Qhov no ua rau cov inhibitor los sib tw nrog cov substrate los khi rau qhov chaw nquag, uas muab lub npe sib tw inhibition.
Daim duab 01: Kev Sib Tw Sib Tw hauv Daim Duab
Kev sib tw inhibition tuaj yeem tiv thaiv los ntawm kev ntxiv ntau cov substrate molecules. Qhov no ua rau muaj qhov tshwm sim ntawm cov chaw nquag ntsib cov substrates es tsis yog inhibitor molecules. Feem ntau cov kev sib tw inhibitors raug khi rau qhov chaw ua haujlwm reversibly. Qhov no yog vim tus inhibitor tsis hloov cov duab ntawm qhov chaw nquag.
Kev Tsis Sib Tw Sib Tw yog dab tsi?
Noncompetitive inhibition yog ib hom enzyme inhibition nyob rau hauv uas tus inhibitor txo cov kev ua ntawm ib qho enzyme. Ntawm no, tus inhibitor tuaj yeem khi rau lub enzyme txawm tias lub substrate twb tau khi rau qhov chaw nquag ntawm cov enzyme ntawd. Yog li ntawd, tus inhibitor tsis khi rau qhov chaw nquag. Li no, tsis muaj kev sib tw ntawm cov substrate thiab inhibitor; Qhov no inhibition yog li no hu ua noncompetitive inhibition. Tom qab ntawd, cov substrate thiab cov inhibitor tuaj yeem pom ntawm ib qho enzyme tib lub sijhawm.
Daim duab 2: Kev tsis sib haum xeeb hauv daim duab
Thaum tus inhibitor raug khi rau cov enzyme nrog rau lub substrate, lub substrate tsis tuaj yeem ua rau cov tshuaj tiv thaiv uas xav tau los muab cov khoom lag luam. Noncompetitive inhibitors feem ntau khi rau cov enzyme irreversibly. Qhov no yog vim qhov khi ntawm inhibitor hloov cov duab ntawm qhov chaw nquag thiab qhov chaw nquag tau deactivated.
Cov duab ntawm tus inhibitor yog txawv kiag li ntawm cov substrate vim hais tias tus inhibitor tsis sib tw rau lub active chaw ntawm lub enzyme. Cov inhibitors tsis sib tw khi nrog cov chaw uas nyob ze ntawm qhov chaw nquag. Qhov kev khi no ua rau kev hloov pauv ntawm cov duab ntawm qhov chaw nquag.
Qhov txawv ntawm kev sib tw thiab tsis sib tw yog dab tsi?
Kev Sib Tw Sib Tw vs Tsis Sib Tw Inhibition |
|
| Kev sib tw inhibition yog ib hom enzyme inhibition uas ib qho inhibitor khi rau cov chaw nquag ntawm cov enzyme, tiv thaiv lub substrate los ntawm kev khi rau cov enzyme. | Noncompetitive inhibition yog ib hom enzyme inhibition uas tus inhibitor txo cov kev ua ntawm ib qho enzyme. |
| Sib tw nrog substrate | |
| Kev sib tw inhibitors sib tw nrog cov substrate rau cov chaw nquag. | Noncompetitive inhibitors tsis sib tw nrog cov substrate rau cov chaw nquag. |
| Zoo ntawm Inhibitor | |
| Kev sib tw inhibitors muaj qhov zoo ib yam li cov substrate | Noncompetitive inhibitors muaj cov duab uas txawv ntawm cov duab ntawm substrate. |
| tshwm sim ntawm Enzyme | |
| Lub substrate thiab qhov sib tw inhibitor tsis tuaj yeem pom ntawm ib qho enzyme tib lub sijhawm. | Cov substrate thiab cov tsis sib tw inhibitor tuaj yeem pom ntawm ib qho enzyme tib lub sijhawm. |
| Kev khi txoj kev | |
| Kev khi ntawm kev sib tw inhibitors nrog lub vev xaib nquag yog thim rov qab. | Kev khi ntawm cov tsis sib tw inhibitors nrog lub vev xaib nquag yog irreversible. |
| Txhim kho qhov zoo ntawm qhov chaw nquag | |
| Cov duab ntawm qhov chaw nquag tsis hloov thaum muaj kev sib tw inhibitor khi rau qhov chaw nquag. | Cov duab ntawm qhov chaw nquag hloov pauv thaum tus inhibitor raug khi rau cov enzyme. |
Summary – Competitive vs Noncompetitive Inhibition
Qhov sib txawv tseem ceeb ntawm kev sib tw inhibition thiab tsis sib tw inhibition yog tias hauv kev sib tw inhibition, khi ntawm tus inhibitor tiv thaiv kev khi ntawm lub hom phiaj molecule nrog rau qhov chaw nquag ntawm cov enzyme whereas, nyob rau hauv noncompetitive inhibition, inhibitor txo cov kev ua ntawm ib enzyme.
