Qhov Tseem Ceeb Qhov Sib Txawv - Ib Txoj Kev Sib Nrauj vs Ob Txoj Kev Sib Tw
DNA kev puas tsuaj yog kev hloov pauv ntawm DNA ntu hauv cov khoom siv caj ces. Muaj ntau hom kev puas tsuaj DNA. Ntawm lawv, ib qho strand so thiab ob txoj hlua tawg yog ob hom DNA puas tsuaj uas ua rau kev hloov pauv ntawm cov qauv tshuaj ntawm DNA. Ib txoj hlua tawg yog DNA kev puas tsuaj uas tshwm sim hauv ib txoj hlua tawm ntawm ob txoj hlua li no, tsuas yog ib txoj hlua tsis xws luag hauv ib txoj hlua khi DNA puas. Ob chav strand so yog DNA kev puas tsuaj uas tshwm sim nyob rau hauv ob qho tib si strands li no, cov qauv tshuaj ntawm ob strands yog hloov nyob rau hauv lub ob strand puas. Qhov no yog qhov sib txawv tseem ceeb ntawm ib txoj hlua tawg thiab ob txoj hlua tawg.
Dab tsi yog ib qho Strand Break?
Vim yog vim li cas sib txawv, ib txoj hlua ntawm DNA ob lub helix tuaj yeem raug puas tsuaj. Thaum ib qho strand puas lawm, nws yog hu ua ib txoj hlua tawg. Cov nucleotide ib ntus ntawm ib txoj hlua khi tau hloov pauv hauv hom kev puas tsuaj DNA no. Qab Zib-phosphate caj qaum ntawm ib txoj hlua tau puas thaum lub sij hawm ib txoj hlua tawg. Ib txoj hlua tawg yog hom kev puas tsuaj DNA feem ntau pom hauv cov kab mob. Nws tau hais tias ib leeg strand so muaj ntau zaus ntawm qhov tshwm sim ntawm ib lub xovtooj ntawm ib hnub vim yog intracellular metabolites thiab spontaneous DNA decay.
Ib txoj hlua tawg tuaj yeem kho tau yooj yim los ntawm ntau lub tshuab kho. Thaum ib qho strand puas lawm, cov hlua txuas ntxiv tuaj yeem siv los ua txoj hlua khi los kho qhov kev puas tsuaj. Cov txheej txheem kho cov txheej txheem sib txawv pab kho cov nucleotides tsis raug lossis puas lawm. Lawv yog lub hauv paus excision kho, kho tsis sib haum, kho nucleotide excision, thiab lwm yam.
Daim duab 01: Ib leeg Strand Break
Muaj ntau yam uas ua rau ib leeg tawg xws li Ionizing hluav taws xob, UV, tshuaj lom neeg, dawb radicals thiab lwm yam.
Dab teg Strand Break yog dab tsi?
Ob txoj hlua tawg yog lwm hom DNA puas pom hauv cov khoom siv caj ces ntawm cov kab mob. Ob leeg ntawm cov hlua ntawm ob lub helix tau hloov pauv lossis tawg hauv hom DNA puas. Qab Zib-phosphate caj qaum ntawm ob txoj hlua tawg ntawm ib qho chaw. Yog tias lawv tshwm sim, nws tsim kev puas tsuaj. Thiab lawv nyuaj rau kev kho los ntawm cov txheej txheem kho ib txwm. Txawm li cas los xij, qee qhov kev puas tsuaj tuaj yeem kho tau los ntawm cov txheej txheem kho excision xws li kho ob txoj hlua tawg, kho nucleotide excision thiab lwm yam. Yog tias ob txoj hlua tawg tsis kho, lawv tuaj yeem ua rau muaj kev hloov pauv uas ua rau kev tuag ntawm tes. Thiab tseem tawg strands tuaj yeem ua rau deletions, translocations, thiab lwm yam. Deletions thiab translocations tuaj yeem tshwm sim los ntawm cov teeb meem kev noj qab haus huv loj lossis kab mob xws li mob qog noj ntshav vim kev hloov kho genomic.
Daim duab 02: DNA Ob Chav Strand Break
Piv rau ib leeg strand so, ob txoj hlua tawg tsis tshua muaj tshwm sim hauv cov hlwb. Ob chav strand so yog vim ntau yam xws li UV hluav taws xob, tshuaj lom neeg, irradiation, ionizing hluav taws xob, thiab lwm yam.
Dab tsi yog qhov Zoo sib xws ntawm Ib Txoj Kev Sib Tw thiab Ob Txoj Kev Sib Tw?
- Ib txoj hlua tawg thiab ob txoj hlua tawg yog ob hom DNA puas tshwm sim hauv cov hlwb nyob.
- Nyob rau hauv ob hom, qab zib-phosphate caj qaum tawg.
- Ob leeg tuaj yeem ua rau kev hloov pauv.
- Ob hom kev puas tsuaj tuaj yeem kho los ntawm cov txheej txheem kho cellular.
Dab tsi yog qhov txawv ntawm Ib leeg Strand Break thiab Ob Chav Strand Break?
Single Strand Break vs Ob chav Strand Break |
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| Ib txoj hlua tawg yog DNA kev puas tsuaj uas tshwm sim hauv ib txoj hlua ntawm DNA ob helix. | Ob txoj hlua tawg yog qhov kev puas tsuaj DNA uas tshwm sim hauv ob qho tib si ntawm DNA ob helix. |
| tshwm sim | |
| Ib txoj hlua tawg yog qhov ntau heev. | ob txoj hlua tawg yog qhov sib piv tsis tshua muaj. |
| Ib leeg strand so tuaj yeem kho tau yooj yim los ntawm kev kho cellular. | Ob chav strand so tsis tuaj yeem kho tau yooj yim los ntawm cov txheej txheem kho cellular. |
| Effect | |
| Ib txoj hlua tawg tsis tuag. | ob txoj hlua tawg yog tuag vim lawv ua rau muaj kab mob sib txawv. |
| Qab Zib-Phosphate Backbone | |
| Qab Zib-phosphate qaum ntawm ib txoj hlua tawg ua ib txoj hlua | Qab Zib-phosphate nraub qaum ntawm ob txoj hlua tau tawg ua ob txoj hlua |
Summary – Ib leeg Strand Break vs Ob chav Strand Break
DNA kev puas tsuaj yog ntau hom thiab tshwm sim ntawm cov zaus hauv cov hlwb. Ib txoj hlua tawg thiab ob txoj hlua tawg yog ob hom kev puas tsuaj DNA. Thaum ib txoj hlua tawg, thiab cov qauv tshuaj hloov pauv hauv ib txoj hlua, qhov kev puas tsuaj no yog hu ua ib txoj hlua tawg. Qab Zib-phosphate qaum pob txha ntawm ib txoj hlua tawg hauv ib txoj hlua tawg. Thaum ob txoj hlua tawg vim qhov kev puas tsuaj tshwm sim rau cov pob txha qab zib-phosphate ntawm ob lub strands, qhov kev puas tsuaj no yog hu ua ob txoj hlua tawg. Ib txoj hlua tawg yog hom kev puas tsuaj DNA feem ntau, thiab lawv tau kho los ntawm cov txheej txheem kho kom yooj yim. Txawm li cas los xij, ob txoj hlua tawg yog qhov tsawg, thiab lawv ua rau muaj kev puas tsuaj yog tias tsis kho tam sim ntawd. Lawv tuaj yeem ua rau kev hloov pauv, kev tuag ntawm tes, mob qog noj ntshav thiab lwm yam. Qhov no yog qhov sib txawv ntawm ib txoj hlua tawg thiab ob txoj hlua tawg.
Download the PDF Version of Single Strand Break vs Ob Strand Break
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov rub tawm PDF version ntawm no: Qhov Sib txawv Ntawm Ib Txoj Kev Sib Nrauj thiab Ob Chav Strand Break
