Qhov Tseem Ceeb - Liposome vs Micele
Amphipathic molecules yog tsim los ntawm lub taub hau hydrophilic thiab hydrophobic tails. Yog li ntawd, lawv muaj ib feem ntawm ob qho tib si polar thiab nonpolar. Nyob ntawm seb hom nqi lawv nqa thiab lwm yam tsis, amphipathic molecules tuaj yeem muaj ntau hom. Liposome thiab micelle yog amphipathic molecules. Liposomes yog tsim los ntawm ib tug bilayer ntawm amphipathic molecules qhov twg ob txheej ntawm molecules yog teem nyob rau hauv ob concentric voj voog. Micelles yog kaw lipid monolayers qhov twg cov fatty acids yog tam sim no nyob rau hauv cov tub ntxhais los yog ntawm qhov chaw. Qhov no yog qhov sib txawv tseem ceeb ntawm liposomes thiab micelles.
Liposome yog dab tsi?
Liposomes yog cov qauv uas muaj cov txheej txheem bilayer ntawm amphipathic molecules qhov twg ob txheej ntawm cov molecules tau teeb tsa hauv ob lub voj voog. Nyob rau hauv qhov kev npaj ntawm molecules, txheej txheej hydrophilic lub taub hau yog teem rau qhov chaw uas lawv tau taw qhia tawm sab nraud nthuav tawm rau sab nrauv. Lub hauv paus hydrophilic core yog tsim los ntawm hydrophilic hau ntawm lub puab txheej. Lub hydrophobic tails ntawm ob txheej yog teem rau ntawm ob qho tib si concentric rings.
Kev tsim ntawm liposome tshwm sim los ntawm cov txheej txheem uas cov lipid qhuav molecules hydrated los ntawm cov kuab tshuaj nonpolar uas tau ua raws li cov txheej txheem agitation (mechanical induction). Lub hauv paus tseem ceeb rau kev tsim liposome yog phospholipid molecules nrog rau cov roj cholesterol. Hom liposomes txawv raws li lawv tsim. Cov txheej txheem ntawm kev faib liposome no nyob ntawm seb qhov ua rau muaj kev ntxhov siab thiab kev siv cov polar hnyav hauv qee zaus. Cov hom liposomes muaj xws li Me Unilamellar Vesicles (SUV), Loj Unilamellar Vesicles (LUV), Loj Multilamellar Vesicles (MLV) thiab Multivesicular Vesicles (MVV).
Daim duab 01: Liposome
Nyob rau hauv tib neeg lub cev, liposomes yog coj los ntawm cov kabmob uas muaj nplua nuj nyob rau hauv reticuloendothelial system. Yog li lub hom phiaj tseem ceeb ntawm liposomes yog kev xa tshuaj, uas yog tsom rau cov kabmob no. Txhawm rau txhawm rau tsom cov qog qog, cov liposomes yog coated nrog cov polymers tshwj xeeb. Cov txheej txheem tsim cov liposomes txheeb ze yog kim. Yog li, cov liposomes no tsuas yog siv thaum kho kab mob kis kab mob thiab tua cov qog cell. Kev tswj hwm tshuaj tau ua tiav los ntawm txoj kev parenteral.
Micelle yog dab tsi?
Micelle txhais tau tias yog lipid molecule uas tau teem rau hauv daim ntawv kheej kheej hauv cov kua dej. Micelles yog tsim nyob rau hauv teb rau amphipathic xwm ntawm fatty acids. Micelles yog tsim los ntawm ob thaj chaw hydrophilic thiab thaj chaw hydrophobic. Cov cheeb tsam hydrophilic yog cov polar taub hau pawg thaum lub cheeb tsam hydrophobic yog cov hlua ntev hydrophobic (tails). Cov pawg polar taub hau feem ntau koom nrog hauv kev tsim cov txheej txheem sab nraud ntawm cov micelles vim lawv muaj peev xwm cuam tshuam nrog dej vim lawv qhov polar xwm. Cov tails hydrophobic muaj nyob rau hauv cov qauv los tiv thaiv kev cuam tshuam nrog dej vim lawv qhov xwm txheej tsis muaj polar.
Cov roj ntsha uas tsim los ntawm micelles muaj ib txoj hlua hydrocarbon nyob rau hauv kev coj mus rau ob txoj hlua hydrocarbon. Cov qauv no ua rau cov fatty acids tsim cov duab kheej kheej thiab yog li nws txo qis kev cuam tshuam steric uas tshwm sim hauv cov fatty acid molecules lawv tus kheej. Qhov ntau thiab tsawg ntawm cov micelles txawv ntawm 02 nm txog 20 nm. Qhov loj me yog nyob ntawm qhov muaj pes tsawg leeg thiab concentration ntawm micelles. Vim lub amphipathic xwm ntawm lub molecule, micelles tsim spontaneously nyob rau hauv dej thiab.
Daim duab 02: Micele thiab Liposome
Nyob rau hauv lub ntsiab lus ntawm tib neeg lub cev, micelles pab nyob rau hauv kev nqus ntawm lipid thiab fat-soluble vitamins xws li vitamin A, D, E thiab K. Lawv kuj pab cov hnyuv me nyob rau hauv kev nqus ntawm cov lipids tseem ceeb thiab cov vitamins derived. los ntawm daim siab thiab lub gallbladder.
Dab tsi yog qhov zoo sib xws ntawm Liposome thiab Micele?
- Ob leeg liposome thiab micelles yog tsim los ntawm amphipathic molecules.
- Ob leeg liposome thiab micelle yog cov qauv vesicular.
- Ob leeg liposome thiab micelle muaj cov ntawv thov tshuaj tseem ceeb.
- Ob leeg liposome thiab micelle ua lub luag haujlwm tseem ceeb hauv kev xa tshuaj.
- Kev tsim ntawm ob qho tib si liposome thiab micelles nce ntau dua li qhov kub thiab txias.
Qhov txawv ntawm Liposome thiab Micele yog dab tsi?
Liposome vs Micele |
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| Liposome yog ib lub qauv uas muaj ib tug bilayer ntawm amphipathic molecules uas ob txheej ntawm molecules yog teem nyob rau hauv ob concentric voj voog. | Micelle yog cov qauv ntawm lipid molecules uas tau teem rau hauv ib daim ntawv kheej kheej hauv cov kua dej. |
| Cov neeg tsim khoom | |
| Liposomes yog tsim los ntawm phospholipid molecules xws li roj cholesterol thiab lwm yam. | Micelles yog tsim los ntawm surfactant molecules xws li detergents, emulsifiers thiab lwm yam. |
| Liposome tsim tshwm sim ntawm qhov hloov pauv kub. | Kraft kub yog qhov ntsuas kub tsawg kawg nkaus ntawm kev tsim micelle. |
Summary – Liposome vs Micele
Amphipathic molecules muaj ib nrab polar thiab ib nrab cov khoom tsis muaj polar. Liposomes thiab micelles poob rau hauv qeb ntawm amphipathic molecules. Cov liposomes yog tsim los ntawm ib tug bilayer ntawm amphipathic molecules qhov twg ob txheej ntawm molecules yog teem nyob rau hauv ob concentric voj voog. Kev tsim ntawm liposome tshwm sim los ntawm cov txheej txheem uas cov lipid qhuav molecules yog hydrated los ntawm cov kuab tshuaj tsis muaj polar. Nws yog ua tiav nrog lub cev agitation. Liposomes tsuas yog siv thaum kho kab mob kis kab mob thiab tua cov qog cell vim cov txheej txheem tsim khoom kim heev. Micelles yog kaw lipid monolayers qhov twg cov fatty acids yog tam sim no nyob rau hauv cov tub ntxhais los yog ntawm qhov chaw. Micelles pab nyob rau hauv kev nqus ntawm lipid thiab fat-soluble vitamins; vitamin A, D, E thiab K. Qhov no yog qhov txawv ntawm liposome thiab micelle.
