Qhov Tseem Ceeb Qhov txawv - Atheroma vs Atherosclerosis
Atherosclerosis yog ib yam kab mob ntawm cov hlab ntsha uas pom los ntawm kev tsim cov roj deposits hauv phab ntsa hlab ntsha. Cov roj deposits uas tsim los ntawm atherosclerosis yog hu ua atheromas. Qhov no yog qhov sib txawv tseem ceeb ntawm atheroma thiab atherosclerosis. Atherosclerosis yog nyob deb ntawm qhov ua rau mob plawv, cerebral thiab peripheral vascular kab mob thiab yog li ntawd, nws muaj kev tuag thiab kev tuag tus nqi uas tshaj li feem ntau ntawm lwm yam mob.
Atherosclerosis yog dab tsi?
Atherosclerosis yog ib yam mob ntawm cov hlab ntsha uas yog tus cwj pwm los ntawm kev tsim cov roj deposits hauv phab ntsa hlab ntsha. Muaj ntau yam sib txawv thiab comorbidities uas ua rau kev loj hlob ntawm atherosclerosis. Cov kev pab cuam no tuaj yeem muab faib ua ob pawg raws li qhov hloov pauv tau thiab cov yam tsis hloov pauv tau.
Modifiable Factors
- Hypertension
- mob khaub thuas
- Kev haus luam yeeb
Nonmodifiable Factors
- Ntxhais tsis xws luag
- tsev neeg keeb kwm
- nce hnub nyoog
- Txiv neej poj niam
YPathogenesis ntawm Atherosclerosis
"Tshuaj rau kev raug mob" yog qhov kev lees paub dav dav tshaj plaws uas piav qhia txog qhov tshwm sim ntawm tus mob no los ntawm kev sib koom ua ke ntawm cov xwm txheej uas tau hais tseg saum toj no nrog cov xwm txheej pathological tshwm sim hauv phab ntsa hlab ntsha. Qhov kev xav no qhia txog xya kauj ruam mechanism rau kev txhim kho ntawm atheroma.
- Endothelial raug mob thiab ua haujlwm tsis zoo uas ua rau nce vascular permeability, leukocyte adhesion thiab qhov muaj feem ntawm thrombosis.
- Cov lipids hauv cov phab ntsa ntawm cov hlab ntsha - LDL thiab nws cov oxidized cov ntaub ntawv yog hom roj uas sib sau ntau.
- Monocyte adhesion rau endothelium - cov monocytes no ces tsiv mus rau hauv intima thiab hloov mus ua npuas hlwb lossis macrophages.
- Platelet adhesion
- Platelets, macrophages thiab ntau yam ntawm cov hlwb uas tau khaws cia ntawm qhov chaw raug mob pib tso tawm cov tshuaj sib txawv sib txawv uas pib ua haujlwm ntawm cov leeg nqaij leeg los ntawm kev tshaj tawm lossis los ntawm cov khoom ua ntej.
- Cov neeg ua haujlwm tau txais cov leeg nqaij du proliferate thaum sib txuas cov tshuaj matrix extracellular thiab nyiam T hlwb ntawm lub nkoj puas.
- Lipid accumulates ob qho tib si extracellularly thiab intracellularly (hauv macrophages thiab cov leeg nqaij du) tsim cov atheroma.
Morphology ntawm Atherosclerosis
Ob chav kos cim morphological yam ntxwv ntawm atherosclerosis yog muaj cov rog streaks thiab atheromas.
Fatty streaks muaj foamy macrophages uas muaj lipids. Thaum pib, lawv tshwm raws li me me daj me ntsis thiab tom qab ntawd lawv coalesce, tsim streaks uas feem ntau yog nyob ib ncig ntawm 1cm ntev. Txij li thaum lawv tsis txaus siab los ntawm qhov chaw, cov ntshav ntws los ntawm lub nkoj tsis cuam tshuam. Txawm hais tias cov rog rog tuaj yeem nkag mus rau hauv atheromas, feem ntau ntawm lawv ploj mus. Cov aortas ntawm cov menyuam mos noj qab haus huv thiab cov tub ntxhais hluas tuaj yeem muaj cov rog rog no.
(Morphology ntawm atheromas yog tham nyob rau hauv nqe lus "atheroma")
Daim duab 01: Cov theem ntawm Endothelial Dysfunction hauv Atherosclerosis
Cov Teeb Meem ntawm Atherosclerosis
Atherosclerosis feem ntau cuam tshuam rau cov hlab ntsha loj xws li aorta thiab cov hlab ntsha nruab nrab xws li cov hlab ntsha coronary. Txawm hais tias nws muaj peev xwm ua tau rau cov txheej txheem pathological no tshwm sim nyob txhua qhov chaw hauv lub cev, ib tus neeg tuaj yeem ua cov tsos mob tsuas yog thaum atherosclerosis ua rau cov hlab ntsha uas muab cov ntshav rau lub plawv, lub hlwb thiab qis qis. Yog li, cov teeb meem loj ntawm atherosclerosis yog,
- mob plawv mob plawv
- Cerebral infarction
- Aortic aneuryms
Atheroma yog dab tsi?
Cov roj deposits tsim nyob rau hauv cov phab ntsa hlab ntsha vim yog cov atherosclerosis hu ua atheromas. Cov no yog cov kab mob intimal uas tsim los ntawm cov lipid core uas npog los ntawm fibrous cap.
Morphology ntawm Atheroma
Atherosclerotic plaques muaj cov xim daj daj uas muaj xim dawb tab sis muaj cov thrombus superimposed tuaj yeem muab xim liab liab rau cov quav hniav. Lawv protrude rau hauv lub lumen ntawm cov hlab ntsha impeding cov ntshav ntws los ntawm cov hlab ntsha. Plaques yog tsim nyob rau hauv ntau qhov ntau thiab tsawg, tab sis lawv tuaj yeem coalesce rau hauv cov loj loj uas muaj peev xwm ua tiav tag nrho cov vascular lumen.
Daim duab 02: Atheroma
Ib atheroma muaj peb yam tseem ceeb:
- Smooth leeg, macrophages, T hlwb
- Extracellular matrix muaj collagen, elastic fibers thiab proteoglycan
- Intracellular thiab extracellular lipid
Raws li tau hais los saum toj no, atheroma muaj lub hau fiber ntau ua los ntawm cov leeg nqaij du thiab ntom collagen fibers. Hauv qab lub kaus mom no yog cov roj uas tau sau rau ntawm qhov chaw puas nrog rau lwm cov hlwb thiab cov khib nyiab. Cov ntshav capillaries tshiab pib tshwm nyob ib ncig ntawm qhov chaw ntawm qhov txhab, thiab qhov tshwm sim no hu ua Neovascularization. Tsis zoo li cov atheromatous plaques, fibrous atheromas muaj cov roj tsawg heev, thiab lawv feem ntau yog ua los ntawm cov ntaub so ntswg sib txuas thiab cov leeg nqaij. Thaum lub sij hawm, atheromas maj mam loj thiab tau calcified. Qhov calcification no ua rau cov phab ntsa ntawm cov hlab ntsha, ua rau nws tsis ua raws thiab ua rau muaj kev pheej hmoo ntawm cov kab mob coronary arterial.
Kev kho mob tseem ceeb Pathological hloov pauv ntawm Atheromas
- Rupture, ulceration los yog yaig ntawm lub fibrous cap exposes lub hauv paus thrombogenic tshuaj uas ua rau thrombosis.
- Hemorrhage into a plaque
- Atheroembolism
- Kev tsim ntawm aneurysms
Qhov txawv ntawm Atheroma vs Atherosclerosis yog dab tsi?
Atheroma vs Atherosclerosis |
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| Atherosclerosis yog ib yam mob ntawm cov hlab ntsha uas yog tus cwj pwm los ntawm kev tsim cov roj deposits hauv phab ntsa hlab ntsha. | Cov roj deposits tsim nyob rau hauv cov phab ntsa hlab ntsha vim yog cov atherosclerosis hu ua atheromas. |
| kev sib raug zoo | |
| Atherosclerosis yog txheej txheem pathological. | Atheromas yog cov khoom ntawm atherosclerosis. |
Summary – Atheroma vs Atherosclerosis
Atheromas yog cov roj deposits tsim nyob rau hauv cov hlab ntsha phab ntsa whereas atherosclerosis yog ib tug pathological mob ntawm cov hlab ntsha uas yog yus muaj los ntawm kev tsim cov roj deposits nyob rau hauv lub arterial phab ntsa. Qhov no yog qhov sib txawv ntawm atheroma thiab atherosclerosis. Raws li tau hais los saum no, kev noj zaub mov kom zoo, kev tawm dag zog, thiab kev tswj tus kheej kom nyob deb ntawm cov luam yeeb txo qhov kev pheej hmoo ntawm atherosclerosis. Yog tias koj muaj cov xwm txheej txaus ntshai no, nws yog ib qho tseem ceeb kom tshem tawm lawv sai li sai tau kom ua neej nyob ntev thiab noj qab nyob zoo.
Download PDF Version of Atheroma vs Atherosclerosis
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Atheroma thiab Atherosclerosis.
